Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.108 (lactase)
 2,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to determine the effects of a model of intestinal extrinsic denervation on mucosal structure and function. Six dogs underwent in situ neural isolation of the jejunoileum (Group 2); six other dogs served as operated controls (Group 1), and five nonoperated dogs were naive controls (Group 3). Thirty-centimeter segments of proximal jejunum and distal ileum were excised before (time zero) and at 2 weeks and 8 weeks postoperatively in Groups 1 and 2, while similar regions were removed at time zero in Group 3. Tissues were analyzed for morphology with quantitative morphometry, mucosal disaccharidase activities (sucrase, maltase, and lactase), and tissue content of selected regulatory peptides in transmural, mucosa/submucosa, and muscularis regions. In situ neural isolation had no significant or consistent effects on morphology/morphometry or on mucosal disaccharidase activities. Tissue content of neuropeptide Y decreased markedly (P < 0.002) in all layers of the jejunal and ileal walls, but tissue content of vasoactive inhibitory polypeptide, substance P, cholecystokinin, neurotensin, met-enkephalin, neurokinin A, somatostatin, and calcitonin gene-related peptide demonstrated only minor changes. The physiologic effects of intestinal transplantation (extrinsic denervation and disruption of intrinsic, enteric neural continuity, and lymphatic drainage) have little effect on morphology, mucosal disaccharidase activity, and tissue content of most regulatory peptides. How these minor alterations might affect enteric function, however, needs to be investigated.
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PMID:Neural isolation of the jejunoileum. Effect on tissue morphometry, mucosal disaccharidase activity, and tissue peptide content. 865 18

Our aim of the study was to find out whether hypolactasia contributes to the development of osteoporosis. In our investigations were involved children of 10-14 years (n = 22) and postmenopausal women of 50-60 years (n = 11). The subjects were assigned to two groups-lactase-normal and lactase-deficient groups. We have analysed calcium intake in the diet, urinary excretion of calcium, serum calcium, serum phosphate, serum parathormone and calcitonin. In children (10-14 years) with lactase deficiency and osteoporosis the mean value of calcium intake was smaller (540-670 mg per day) than in patients of the lactase-normal group (on average 820 mg per day). In children osteoporosis has developed 2-10 years after the hypolactasia diagnosis. In the group of postmenopausal women (50-60 years) calcium intake was smaller in the lactase-deficient group with osteoporosis (average 630 mg per day), in the lactase-normal group in postmenopausal women calcium intake was normal (about 1200 mg per day). Urinary excretion of calcium (per 24 h) and other laboratory analyses did not differ in patients with hypolactasia from patients of the lactase-normal group. Lactase deficiency appears to be one of several factors that predispose the development of osteoporosis, probably through diminished calcium intake.
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PMID:Nutrition in prevention of osteoporosis. 896 95