Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.108 (lactase)
 2,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The control of weaning was studied in rat pups aged 17-24 days. The influence of two hormones, thyroxine (T4) and corticosterone, and the effect of declining intestinal lactase activity were evaluated. Hypothyroidism was induced by administration of n-propylthiouracil and hyperthyroidism was induced by injection of T4. Hypothyroid pups failed to begin nibbling chow while littermates injected with T4 weaned normally. Two abnormalities resulting from hypothyroidism, hypothermia and stunted incisors, were not responsible for the lack of weaning in hypothyroid pups. Hyperthyroidism did not cause precocious weaning. Glucocorticoid levels were manipulated by both adrenalectomy (ADX) and administration of corticosterone. ADX pups exhibited a delayed pattern of weaning while both ADX pups injected with corticosterone and sham-operated pups weaned normally. Corticosterone injected before its normal developmental surge did not cause precocious weaning. Lactase activity, measured throughout these experiments, did not consistently reflect the degree of weaning progression. We conclude that 1) the hormones, T4 and corticosterone, are necessary for the onset of weaning, but neither is a sufficient stimulus to initiate weaning, and 2) low lactase activity does not initiate weaning.
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PMID:Weaning in the rat: a study of hormonal influences. 640 84

Glycolysis was studied in people with fibromyalgia syndrome (FMS), hypothyroidism (HO), chronic osteoarticular pain (OACP), and normal control subjects. Comparisons between the controls and the three study groups revealed increased pyruvate and increased lactate (L) production in FMS and HO; decreased adenosine triphosphate (ATP) and lactase dehydrogenase (LDH) isoenzymes in FMS only; and no glycolytic impairment in OACP.
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PMID:Is fibromyalgia caused by a glycolysis impairment? 809 Mar 78

To assess the effects of hypothyroidism (HT) on small-intestinal function, HT was induced in rats (120-150 g) by methimazole in drinking water. After 6 wk of methimazole, intestinal absorption studies were performed in HT and in control (C) rats by in situ luminal perfusion of a 20-cm proximal jejunal loop with a bicarbonate buffer containing sodium, glucose or fructose, glycine or lysine, and phenol red as a nonabsorbable marker for determination of water fluxes. Mucosa from the perfused segment was taken for assay of disaccharidases and ATPases and for light and electron microscopy. Compared with C rats, HT rats had significantly lower jejunal transport rates of water (2.54 +/- 0.36 versus 5.02 +/- 0.7 microL/min/microgram mucosal protein, p < 0.03), sodium (37.1 +/- 10.3 versus 102.7 +/- 18.6 mumol/min/microgram protein, p < 0.05), and glucose (1.49 +/- 0.28 versus 5.17 +/- 0.82 mumol/min/microgram protein, p < 0.02). A reduction in glycine transport was also observed but did not attain statistical significance (p = 0.058). Fructose and lysine transport was unchanged. Mucosal sucrase and lactase activities were similar in both groups, but Na,K-ATPase was significantly lower in HT rats (1.17 +/- 0.3 versus 4.03 +/- 1.5 mumol inorganic phosphate/h/mg protein; p < 0.05), with a diminution of ouabain binding sites by 41.5%. Light microscopy of jejunal mucosa from HT rats did not differ from that from C rats; electron microscopy showed mild mitochondrial swelling in HT enterocytes. A group of HT rats were treated with L-thyroxine during 4 wk; these rats had absorption rates, mucosal enzyme activities, ouabain binding, and mucosal morphology not different from C rats.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effects of hypothyroidism on jejunal mucosal function: study by in situ luminal perfusion in rats. 839 45