Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.12 (
chondroitinase
)
2,183
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tenascin-X
(
TN-X
) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of
TN-X
in the extracellular matrix, overlay blot assays were performed on skin extracts. A 100 kDa molecule interacting with
TN-X
was identified by this method and this interaction was abolished when the extract was digested by
chondroitinase
. By solid-phase assays, we showed that dermatan sulfate chains of decorin bind to the heparin-binding site included within the fibronectin-type III domains 10 and 11 of
TN-X
. We thus postulate that the association of
TN-X
with collagen fibrils is mediated by decorin and contributes to the integrity of the extracellular network.
...
PMID:Binding of tenascin-X to decorin. 1132 44
