Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.6.1 (sulfatase)
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Human Gene/Protein
arylsulfatase 13.3
Gal-NAc6S 13.3
MPS4A 13.3
heat shock 70kDa protein 2 13.3
ARSK 13.3
arylsulfatase A 13.3
sulfatase 13.3
steroid sulfatase (STS) 13.1
arylsulfatase B 13.0
Arylsulfatase G 12.9
SUMF1 protein 12.9
Sulfatase modifying factor 1 12.7
Arylsulfatase B 12.6
ARSB 12.5
sulfatase modifying factor 1 12.5
GALNS protein 12.3
sulfatase modifying factor 2 12.3
ARSJ 12.3
cerebroside sulfate activator protein 12.3
estrone sulfatase 12.3
STS protein 12.3
SUMF1 12.2
ARSC 12.2
Arylsulfatase A 12.1
N-acetylglucosamine-6-sulfatase 12.1
MPS VI 11.9
steroid sulfatase 11.9
17beta-HSD type 12 11.7
RYSR 11.7
ARSA 11.7
Xg blood group antigen 11.7
sulfatase 2 11.3
arylsulfatase K 11.3
Tyramine oxidase 11.3
GALNS 11.3
arylsulfatase E 11.2
ARSI 11.0
3-OST-5 10.7
GALN 10.7
BRAG 10.7
CLN6 protein 10.7
Alkaline phosphomonoesterase 10.7
sulfatase 1 10.7
HSulf-1 10.6
MPS IIIA 10.5
Gal3ST-3 10.5
cerebroside sulfotransferase 10.4
ASB 10.4
HGSNAT 10.3
Estrogen sulfotransferase 10.3
MPS7 10.3
MSD 10.2
ion transporter protein 10.1
PPGB 10.1
SULF2 10.0
plasma glutamate carboxypeptidase 10.0
SYCP2L 10.0
RNF139 10.0
HSD17B14 9.8
Gal3ST-2 9.8
ESkine 9.8
IDS protein 9.8
17beta hydroxysteroid dehydrogenase 9.8
Phosphomonoesterase 9.6
GRAP 9.6
SAP-1 9.6
SULT1E1 9.6
STE 9.5
FGE 9.5
CAH1 9.5
17beta-hydroxysteroid dehydrogenase 9.4
PNPLA4 9.4
iduronate-2-sulfatase 9.3
gene/pseudogene 9.2
LARGE1 9.2
chondroitin 4-sulfotransferase 9.1
Proline-, glutamic acid- and leucine-rich protein 1 9.1
Exostosin-1 9.1
HSD17B7 9.1
HSA5 9.0
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Disease
MPS VIII 13.3
Deficiency of arylsulfatase 13.0
MPS VI 11.7
MPS IIID 11.6
metachromatic leukodystrophy 11.5
torsion spasm 11.0
Morquio A syndrome 10.7
Rud syndrome 10.4
MPS IIIA 10.0
Morquio 9.7
MSD 9.7
Sanfilippo 9.6
lysosomal storage disease 9.4
mucopolysaccharidosis 9.3
Brailsford 9.1
Sanfilippo syndrome 9.1
CDPX1 9.0
MPS II 9.0
sphingolipidosis 8.9
ML III 8.8
hebephrenia 8.5
Mucolipidosis 8.5
STS 8.4
MPS IIIC 8.4
MPS IVB 8.3
warfarin embryopathy 8.2
Segmental demyelination 8.1
49,XXXXY syndrome 8.1
Ichthyosis vulgaris 8.0
Chondrodysplasia punctata 7.9
ichthyosis 7.8
C syndrome 7.8
inv(X) 7.7
ichthyosis 7.7
Rokitansky-Aschoff sinuses 7.6
HSAN1 7.5
enzyme deficiency 7.4
GM1 gangliosidosis 7.4
Hurler 7.3
XX males 7.2
Escherichia coli meningitis 7.1
Richner-Hanhart syndrome 7.1
LINCL 7.1
chondrodysplasia 7.0
Pelizaeus-Merzbacher 7.0
breast fibroadenoma 6.9
Sandhoff disease 6.9
lipidosis 6.9
Krabbe disease 6.8
sialidosis 6.8
Infantile neuronal ceroid lipofuscinosis 6.8
Medulla 6.8
splenic disease 6.7
MPS I 6.7
IVA 6.7
Inborn errors of metabolism 6.6
delayed language 6.6
leukodystrophy 6.6
Kufs' disease 6.6
Klebs 6.5
NNH 6.5
SRS 6.4
Recurrent aphthous stomatitis 6.4
CLN6 6.4
DMC 6.3
Dystrophic epidermolysis bullosa 6.3
Tay-Sachs disease 6.2
GS1 6.2
Hydrops fetalis 6.1
CNS cancer 6.1
gangliosidosis 6.1
Pelizaeus-Merzbacher disease 6.1
Conradi 6.0
Cardiac rupture 5.9
MPS VII 5.9
caruncle 5.8
nasal allergy 5.7
Malassez 5.7
mannosidosis 5.7
Growth failure 5.6
more...
Symptom
Macula 6.4
scaly skin 5.9
Neurologic symptoms 5.8
disturbed balance 5.4
joint stiffness 5.2
ataxic gait 5.2
meningism 4.9
hepatosplenomegaly 4.9
Spots 4.5
lightheadedness 4.3
hypotonia 4.1
neck stiffness 4.0
anosmia 3.7
cerebellar ataxia 3.5
spasticity 3.4
hepatomegaly 3.4
Stiffness 3.3
dry skin 3.3
microbial colonization 3.2
abnormal gait 3.1
muscle stiffness 3.0
masculinization 3.0
chronic constipation 3.0
myoclonus 2.8
starvation 2.7
incoordination 2.5
memory loss 2.5
spasm 2.4
dysarthria 2.4
lethargy 2.4
twitching 2.3
skin irritation 2.2
ataxia 2.1
dry eye 1.9
asthenia 1.9
paraparesis 1.8
dystonia 1.8
cachexia 1.8
HSA 1.7
colic 1.6
ophthalmoplegia 1.6
pelvic pain 1.3
regurgitation 1.3
weakness 1.1
nausea and vomiting 1.0
constipation 1.0
numbness 0.9
hunger 0.8
agitation 0.7
seizures 0.7
flushing 0.6
vertigo 0.5
arthralgia 0.5
tremor 0.1
splenomegaly 0.0
low back pain -0.0
angina -0.1
insomnia -0.1
vomiting -0.1
Ill -0.2
thinning -0.2
sleepiness -0.4
erythema -0.4
overweight -0.4
functional recovery -0.4
chest pain -0.8
hypothermia -0.8
anesthesia -0.9
respiratory distress -1.0
nausea -1.2
analgesia -1.5
diarrhea -1.5
pain -1.5
abdominal pain -1.6
headache -2.5
Drug
Galsulfase 12.3
Sodium picosulfate 9.7
Sulfamide 9.2
Equilenin 9.1
Gardenia fruit 9.1
Calcium citrate 8.7
Pizotifen 8.6
Tibolone 8.3
Nabilone 7.6
Sodium ascorbate 7.5
NYS 7.5
Polysorbate 20 7.4
Chloramine T 7.4
Dienogest 7.0
Micafungin 6.6
Tramal 6.6
Perphenazine 6.6
beta-Galactosidase 6.5
Trilostane 6.5
Estriol 6.5
Sesamol 6.4
Poudre 6.4
Protamine sulfate 6.3
Compound 15 6.3
Cellulose acetate 6.2
Estrogens 5.6
Rutin 5.5
Hyaluronidase 5.5
Hyaluronidase 5.3
niacin 5.2
Pregnenolone 5.1
Premarin 5.0
Myricetin 5.0
Fondaparinux 4.9
DHT 4.8
TRM 4.7
Tannic acid 4.7
DHT 4.7
EE2 4.7
Zoledronic acid 4.6
Dihydrotestosterone 4.6
Emodin 4.4
L-tyrosine 4.4
Ginger 4.4
KGF 4.4
Galactose 4.3
Orphan 4.2
Streptokinase 4.1
Emodin 4.1
CFT 4.1
-deoxyadenosine 3.8
Camp 3.8
Raloxifene 3.8
ABC 3.8
DFP 3.4
Gel 3.4
Mutagen 3.3
TAK 3.3
Salbutamol 3.3
ICI 3.2
IL-11 3.2
Azithromycin 3.0
Scopolamine 2.9
Pronase 2.9
NBT 2.9
ascorbate 2.9
Vitamin K 2.8
Prednisolone 2.7
Triclosan 2.6
TAC 2.6
Tacrolimus 2.6
Kenyan 2.5
Norplant 2.5
Docetaxel 2.5
MAP 2.3
Theophylline 2.3
PCB 2.2
NAG 2.2
NADH 2.2
TMS 2.1
more...
Enzyme
choline-sulfatase 13.3
sulfatase 13.3
arylsulfatase A 13.3
galactose-6-sulfatase 13.0
arylsulfatase 12.9
N-acetylglucosamine-6-sulfatase 12.2
chondro-6-sulfatase 12.0
3-KSR 11.7
glucuronate-2-sulfatase 11.7
chondro-4-sulfatase 11.1
phosphoglycerol transferase 11.1
EC 5.4.99.15 11.0
N-sulfoglucosamine sulfohydrolase 10.7
estrogen sulfotransferase 10.6
glycosulfatase 10.5
glycuronidase 10.3
iduronate-2-sulfatase 10.3
CMP-sialic acid:lactosylceramide sialyltransferase 10.3
chondroitinase 10.2
heparan-alpha-glucosaminide N-acetyltransferase 9.7
estrogen sulfotransferase 9.6
trimetaphosphatase 9.5
GSase 9.3
lactaldehyde dehydrogenase 9.2
beta-glycerophosphatase 9.1
phosphonoacetate hydrolase 9.0
phosphoamidase 9.0
beta-glucuronidase 8.9
arylsulfate sulfotransferase 8.9
galactocerebrosidase 8.9
chondroitin 4-sulfotransferase 8.8
nicotinamidase 8.8
alpha-N-acetylglucosaminidase 8.7
alpha-L-iduronidase 8.6
choline dehydrogenase 8.6
N-acetylglucosaminylphosphotransferase 8.5
N-acetylgalactosaminidase 8.5
GDPase 8.5
17beta-HSD 8.4
phosphonatase 8.4
alpha-N-acetylglucosaminyl phosphodiesterase 8.4
phosphopentomutase 8.4
chondroitinase B 8.4
UDP-galactose:ceramide galactosyltransferase 8.4
beta-D-fucosidase 8.3
SOAT 8.2
alpha-L-fucosidase 8.2
17beta-HSD 8.0
hexosaminidase 7.8
glucose-1-phosphate thymidylyltransferase 7.8
chondroitin ABC lyase 7.8
alpha-mannosidase 7.8
alpha-L-fucosidase 7.7
alpha-L-fucosidase 7.5
site-1 protease 7.5
chondroitinase 7.5
myrosinase 7.4
beta-glucosidase 7.3
betaine aldehyde dehydrogenase 7.3
beta-glucosidase 7.2
acid phosphatase 7.2
alpha-N-acetylgalactosaminidase 6.9
heparitinase I 6.9
butyryl-CoA dehydrogenase 6.9
acrosin 6.9
DNase II 6.9
coproporphyrinogen III oxidase 6.8
SsuE 6.7
cathepsin D 6.7
beta-xylosidase 6.6
cystathionine beta-lyase 6.6
chondroitinase AC 6.6
hyaluronate lyase 6.6
alpha-galactosidase 6.5
urease 6.5
aspartylglucosaminidase 6.5
urease 6.5
site-1 protease 6.5
endoglycosidase H 6.4
ATP sulfurylase 6.4
more...
Compound
2-(2,4-dichlorophenoxy)ethyl 13.3
Thyroxine sulfate 13.3
2-Hydroxyphenacetin 13.3
N-Acetylglucosamine 6-sulfate 13.3
2-(2,4-dichlorophenoxy)ethyl 13.3
N-Acetylgalactosamine 6-sulfate 13.3
2-(2,4-dichlorophenoxy)ethyl 13.3
2-(2,4-dichlorophenoxy)ethyl 13.3
2-(2,4-dichlorophenoxy)ethanol 13.3
UDP-N-acetylgalactosamine 4-sulfate 12.7
Formylglycine 11.9
4-Methylumbelliferyl sulfate 11.7
Demegestone 11.7
Sinalbin 11.7
Sinalbin 11.3
alpha-Zearalenol 11.3
Promazine hydrochloride 11.3
L-Cysteic acid 11.3
3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one 11.3
7-Hydroxyflavone 10.7
Pronethalol 10.7
Hydroxycitronellal 10.7
Testosterone acetate 10.7
16 alpha-hydroxypregnenolone 10.6
sulfamoyl chloride 10.5
Sulfatide 10.0
3-T1 10.0
1,2,3,4-tetrahydrophenanthrene 10.0
Sodium picosulfate 10.0
Promegestone 9.8
6-hydroxy-2-naphthoic acid 9.8
Diiodothyronine 9.7
Cholesterol sulfate 9.6
Norathyriol 9.2
11beta-hydroxyandrosterone 9.2
Premarin 9.2
iduronate 9.1
7-methoxy-2H-chromen-2-one 9.1
Fast Garnet GBC 9.0
4-methyl-2H-chromen-2-one 8.9
Equilenin 8.9
Estrone 8.8
2-adamantanone 8.7
Indoxyl 8.6
3,4-D 8.6
gamma-CEHC 8.6
Colprone 8.5
Scutellarein 8.5
CMP-N-acetylneuraminate 8.4
MSTFA 8.4
CMP-N-acetylneuraminate 8.4
keratan sulfate 8.3
alpha-CEHC 8.1
2-hydrazinopyridine 8.1
3-pyridinol 8.1
Cresol 8.0
GalNAc4S 8.0
Girard's reagent T 8.0
Dehydroepiandrosterone sulfate 8.0
M1A 8.0
3,5-T2 7.9
2,3,4,6-tetrachlorophenol 7.8
N-Acetylglucosamine 7.7
Borneol 7.7
Sulfoxide 7.6
Tetrahydrocurcumin 7.6
hexacosanoic acid 7.6
MOCA 7.4
9H-pyrido[2,3-b]indole 7.4
N-acetyltryptophan 7.4
UDP-N-acetylgalactosamine 7.4
N-acetyltryptophan 7.3
Eriodictyol 7.3
4-methyl-2-pentanone 7.3
4-Methylumbelliferone 7.3
4-methyl-2-pentanone 7.3
ICI 164384 7.2
Azure A 7.2
Metaproterenol 7.2
Heparan sulfate 7.2
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