Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The sorting of newly synthesized mannose 6-phosphate (M6P)-containing proteins and of the
major excreted protein (MEP)
, a lysosomal thiol proteinase, was studied in NIH-3T3 cells transfected with the cDNA of human insulin-like growth factor II (IGF II) or with the vector alone. Extracts from media and cells labelled with [35S] methionine were used for chromatography on a M6P/IGF II receptor affinity matrix or for immunoprecipitation to assess the distribution of newly synthesized M6P-containing proteins and
MEP
, respectively. The results indicate that the overexpression of IGF II did not affect the synthesis and the sorting of M6P-containing proteins and of
MEP
. The binding and uptake of the lysosomal enzyme
arylsulfatase A
were not affected in IGF II overexpressing cells.
...
PMID:Insulin-like growth factor II overexpression does not affect sorting of lysosomal enzymes in NIH-3T3 cells. 167 27
