Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To be active all known arylsulfatases undergo a unique post-translational modification leading to the conversion of an active site residue (serine or cysteine) into a C(alpha)-formylglycine. Although deprived of
sulfatase
activity, Escherichia coli K12 can efficiently mature heterologous Cys-type sulfatases. Three potential enzymes (AslB, YdeM and YidF) belonging to the anaerobic
sulfatase
maturating enzyme family (an
SME
) are present in its genome. Here we show that E. coli could mature Cys-type sulfatases only in aerobic conditions and that knocking-out of aslB, ydeM and yidF does not impair Cys-type
sulfatase
maturation. These findings demonstrate that these putative anSME are not involved in Cys-type
sulfatase
maturation and strongly support the existence of a second, oxygen-dependent and Cys-type specific
sulfatase
maturation system among prokaryotes.
...
PMID:First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants. 1730 25
