Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Comparative in situ hybridization in various primate species has revealed a pseudoautosomal location for the human
ANT3
gene and an X-specific location for the steroid sulfatase (STS) gene throughout the higher primate species up to the New World monkeys. However,
ANT3
and
STS
map together on an autosome of two prosimian species of the genus Lemur and Eulemur. These results suggest an autosome-to-X/Y translocation after the simians radiated from the prosimians, resulting in a pseudoautosomal location of genes such as
ANT3
and
STS
. In simian primates,
STS
then became X-specific by a pericentric inversion in the Y chromosome followed by mutational inactivation of the Y allele.
...
PMID:ANT3 and STS are autosomal in prosimian lemurs: implications for the evolution of the pseudoautosomal region. 781 20
