Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Androgen signal has been recently suggested to be associated with the progression of bladder cancer. Steroid sulfatase (
STS
) is a steroid sulfate activation enzyme, considered to be one of the key enzymes in the androgen signaling pathway. However, the role of
STS
in bladder cancer has not been elucidated. The purpose of the present study was to determine the clinical and functional significance of
STS
in bladder cancer. Immunohistochemical analysis of surgical specimens obtained by radical cystectomy (n=114) demonstrated that overexpression of
STS
was associated with the invasion of bladder cancer, as evidenced by the incidence of
STS
-positive cancers (11.5 and 37.1% in
non-muscle
invasive and muscle invasive bladder cancers, respectively; P=0.003).
STS
-positive cancer demonstrated shorter recurrence-free survival and cancer-specific survival (P=0.0027 and 0.0030, respectively). Furthermore, knockdown of
STS
significantly reduced cell migration and invasion capacities of bladder cancer cells (P<0.001 and P=0.005, respectively), accompanied by the upregulation of E-cadherin and downregulation of vimentin. In summary, the present study demonstrated that
STS
promotes the invasion capability of bladder cancer via regulation of the epithelial-mesenchymal transition, and may be a useful marker for predicting the progression of bladder cancers.
...
PMID:Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer. 3054 96
