Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.6.1 (sulfatase)
 3,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The availability of the oral contraceptive steroids ethinyl estradiol (EE) and levonorgestrel in plasma after a single dose of 1 g paracetamol (acetaminophen) was quantitated. 6 women aged 21-24 who had been taking combined oral contraceptives for at least 3 months took a single dose of 1 g paracetamol, followed 1 hour later by a single dose of Ovran (50 mcg EE and 250 mch levonorgestrel) after an overnight fast. EE and levonorgestrel were radioimmunoassayed, and EE sulfate was determined by radioimmunoassay after incubation with sulfatase. In blood sampled over a 24 hour period, the area under the concentration curve for EE during the 1st 3 hours rose significantly after paracetamol (22%, p0.05). EE sulfate concentration was significantly lower (p0.05). There was no change in plasma concentration of levonorgestrel. The results suggest that paracetamol increases circulating EE by limiting available sulfation of the steroid.
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PMID:Paracetamol interaction with oral contraceptive steroids: increased plasma concentrations of ethinyloestradiol. 311 13