Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Steroid sulfatase (
STS
) increases the pool of precursors of biologically active steroids, thereby playing an important role in breast cancer development. Mechanisms that control
STS
expression remain poorly understood. In present study we investigated alterations in the 5' region of
STS
gene to gain insight into the mechanism(s) that regulates its expression in mammary epithelial cells. We found that at least four
alternatively spliced
transcripts of
STS
gene can be produced from at least four different leader exons. Distinct expression patterns of the
STS
variants were observed in human tissues. Expression profiles of estrogen receptor alpha (ERalpha)-positive and ERalpha-negative breast carcinomas showed that these two categories of tumors and their adjacent benign tissues display remarkably different expression of
STS
isoforms. Coexpression of
STS
isoforms with ER isotypes suggests their cell-type specific coregulation. In addition, we identified ERalpha as essential regulator of
STS
transcription and provide evidence of direct estradiol-dependent binding of ERalpha to multiple
STS
cis-regulatory regions in vivo. Our results indicate that
STS
isoforms are under control of estrogen signaling pathways and their differential expression may play a significant role in breast cancer biology.
...
PMID:Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma. 1759 30
