Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The participation of tyramine oxidase in the regulation of
arylsulfatase
synthesis in Klebsiella aerogenes was studied. Arylsulfatase was synthesized when this organism was grown with methionine or taurine as the sulfur source (nonrepressing conditions) and was repressed by inorganic sulfate or cysteine; this repression was relieved by tyramine and related compounds (derepressing conditions). Under nonrepressing conditions,
arylsulfatase
synthesis was not regulated by tyramine oxidase synthesis. However, derepression of
arylsulfatase
and induction of tyramine oxidase synthesis by tyramine were both antagonized by glucose and other carbohydrate compounds. The derepressed synthesis of
arylsulfatase
, like that of tyramine oxidase, was released from catabolite repression by use of tyramine as the sole source of nitrogen. A mutant strain that exhibits constitutive synthesis of glutamine synthetase and high levels of
histidase
when grown in glucose-ammonium medium was subject to the catabolite repression of both tyramine oxidase and
arylsulfatase
syntheses. Mutants in which repression of
arylsulfatase
could not be relieved by tyramine could not utilize tyramine as the sole source of nitrogen and were defective in the gene for tyramine oxidase.
...
PMID:Tyramine oxidase and regulation of arylsulfatase synthesis in Klebsiella aerogenes. 83 Jun 48
