Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To be active all known arylsulfatases undergo a unique post-translational modification leading to the conversion of an active site residue (serine or cysteine) into a C(alpha)-formylglycine. Although deprived of
sulfatase
activity, Escherichia coli
K12
can efficiently mature heterologous Cys-type sulfatases. Three potential enzymes (AslB, YdeM and YidF) belonging to the anaerobic
sulfatase
maturating enzyme family (an SME) are present in its genome. Here we show that E. coli could mature Cys-type sulfatases only in aerobic conditions and that knocking-out of aslB, ydeM and yidF does not impair Cys-type
sulfatase
maturation. These findings demonstrate that these putative anSME are not involved in Cys-type
sulfatase
maturation and strongly support the existence of a second, oxygen-dependent and Cys-type specific
sulfatase
maturation system among prokaryotes.
...
PMID:First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants. 1730 25
