Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of the polypeptide Decapeptyl (a gonadotropin-releasing hormone (GnRH) agonist analogue) and of
transforming growth factor-alpha
(
TGF-alpha
), on estrone sulfate-
sulfatase
activities in the homogenates of various breast cancer cell lines were studied in the presence of heparin. In hormone-dependent MCF-7 breast cancer cells, Decapeptyl can inhibit
sulfatase
activity, and this effect is significantly augmented in the presence of heparin. In the other hormone-dependent T-47D breast cancer cell line, the decrease of
sulfatase
activity was only significant when Decapeptyl was associated with heparin. No significant effect on
sulfatase
activity elicited by heparin, Decapeptyl or a mixture of both was found in the hormone-independent MDA-MB-231 breast cancer cells.
TGF-alpha
stimulates
sulfatase
activity in the MDA-MB-231 cells but has no effect in the MCF-7 cells; in contrast,
TGF-alpha
combined with heparin provokes a decrease of the
sulfatase
activity in both cell lines. It is concluded that the
sulfatase
activity in some types of breast cancer cell can be inhibited by heparin combined with the polypeptides Decapeptyl or
TGF-alpha
.
...
PMID:Effect of Decapeptyl (a GnRH analogue) and of transforming growth factor-alpha (TGF-alpha), in the presence of heparin, on the sulfatase activity of human breast cancer cells. 774 10
