Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is well known that
mycoplasma
can cause infection in the male reproductive tract. Some studies indicate that Ureaplasma urealyticum (Uu), a species of
mycoplasma
, is associated with male infertility. Sulfogalactosylglycerolipid(SGG) is the major mammalian male germ cell glycolipid, synthesized via sulfation of galactosylglycerolipid in early primary spermatocytes. Some experiments have proved that SGG is implicated in sperm-egg binding by linking
arylsulfatase A
(AS-A), SGG's ligand on the egg. SGG can be desulfated by binding mycoplasmas and transformed galactosylglycerolipid, which doesn't bind AS-A. So the binding and degradation of the sperm SGG by mycoplasmas may play a role in the induction of male infertility. As a kind of
mycoplasma
, Uu can also bind SGG, which offers another explantion for the association of Uu infection with male infertility caused by Uu infection.
...
PMID:[Relationship between mycoplasma infection and germ cell sulfogalactosylglycerolipid]. 1508 72
