Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.6.1 (
sulfatase
)
3,205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is well known that mycoplasma can cause infection in the male reproductive tract. Some studies indicate that Ureaplasma urealyticum (Uu), a species of mycoplasma, is associated with
male infertility
. Sulfogalactosylglycerolipid(SGG) is the major mammalian male germ cell glycolipid, synthesized via sulfation of galactosylglycerolipid in early primary spermatocytes. Some experiments have proved that SGG is implicated in sperm-egg binding by linking
arylsulfatase A
(AS-A), SGG's ligand on the egg. SGG can be desulfated by binding mycoplasmas and transformed galactosylglycerolipid, which doesn't bind AS-A. So the binding and degradation of the sperm SGG by mycoplasmas may play a role in the induction of
male infertility
. As a kind of mycoplasma, Uu can also bind SGG, which offers another explantion for the association of Uu infection with
male infertility
caused by Uu infection.
...
PMID:[Relationship between mycoplasma infection and germ cell sulfogalactosylglycerolipid]. 1508 72
A common defect encountered in the spermatozoa of
male infertility
patients is an idiopathic failure of sperm-egg recognition. In order to resolve the molecular basis of this condition we have compared the proteomic profiles of spermatozoa exhibiting an impaired capacity for sperm-egg recognition with normal cells using label free mass spectrometry (MS)-based quantification. This analysis indicated that impaired sperm-zona binding was associated with reduced expression of the molecular chaperone, heat shock 70 kDa protein 2 (HSPA2), from the sperm proteome. Western blot analysis confirmed this observation in independent patients and demonstrated that the defect did not extend to other members of the HSP70 family. HSPA2 was present in the acrosomal domain of human spermatozoa as a major component of 5 large molecular mass complexes, the most dominant of which was found to contain HSPA2 in close association with just two other proteins, sperm adhesion molecule 1 (SPAM1) and
arylsulfatase A
(
ARSA
), both of which that have previously been implicated in sperm-egg interaction. The interaction between SPAM1,
ARSA
and HSPA2 in a multimeric complex mediating sperm-egg interaction, coupled with the complete failure of this process when HSPA2 is depleted in infertile patients, provides new insights into the mechanisms by which sperm function is impaired in cases of
male infertility
.
...
PMID:The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition. 2320 33
