Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.37 (
CNPase
)
539
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Purified
Newcastle disease
virus (NDV) virions possess 2',3'-cyclic nucleotide 2'-phosphohydrolase (2'-
CNPase
) and
2',3'-cyclic nucleotide 3'-phosphohydrolase
(3'-
CNPase
) activities. These enzyme activities cannot be removed from the virion even after extensive purification by chromatography on controlled-pore glass. In the intact virion, the 3'-
CNPase
activity was stimulated by Triton X-100, while the 2'-
CNPase
activity was partially inhibited. We have prepared the NDV subunits and have shown that 3'-
CNPase
was associated exclusively with the viral nucleocapsid. In contrast, the 2'-
CNPase
activity was associated with both the envelope as well as the nucleocapsid. A threshold amount of both enzyme activities was detected in viral M protein.
...
PMID:Localization of 2',3'-decycling phosphodiesterases in the Newcastle disease virus virion. 198 76
