Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.3 (phospholipase C)
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Human Gene/Protein
PLC-IV 10.8
protein kinase C and casein kinase substrate in neurons 3 10.8
mitochondrial cytochrome c oxidase subunit Va 10.8
myotubularin related protein 7 10.8
PLC-III 10.8
Parkinson disease (autosomal recessive, juvenile) 2, parkin 10.8
SPINT2 protein 10.8
Calmodulin-binding transcription activator 2 10.8
p122-RhoGAP 10.8
Type I phosphoinositide 3-kinase 10.8
phosphatidylinositol-specific 10.7
PLC-II 10.5
phosphoinositide-specific 10.4
PLCeta2 10.3
PLC1 10.2
Phosphoinositide phospholipase C 10.2
PLCzeta 10.2
GTP-binding protein Rab3A 10.0
PLC-I 10.0
ERP60 9.8
transient receptor potential cation channel, subfamily M, member 4 9.8
enkurin 9.8
phospholipase A2, group IVB 9.8
PLCH1 9.8
P2X purinoceptor 2 9.8
Gq class 9.5
PI-PLC 9.5
PLCB3 9.3
WBP2NL 9.3
hGRP 9.3
Phospholipase C 9.3
Galpha14 9.3
PLCE 9.2
Enkurin 9.2
PRLHR 9.2
Bardet-Biedl syndrome 5 9.2
Mono(ADP-ribosyl)transferase 9.2
MAFF protein 9.2
T2R5 9.2
VHCH1 9.2
PIP5KL1 9.2
CD48 protein 9.2
PLCD3 9.2
PLC 9.1
PRIP 9.1
G alpha q 9.1
DSEL 9.1
phosphoinositide phospholipase C 9.0
Galphaz 8.9
PGAP1 8.9
RHC 8.8
Membrane dipeptidase 8.8
LTRPC7 8.8
Mono-ADP-ribosyltransferase 8.8
phospholipase C, zeta 1 8.8
C2GnT-M 8.8
Carcinoembryonic antigen-related cell adhesion molecule 8 8.8
B3GNT8 8.8
PLCE1 protein 8.8
PLCH2 8.8
CEACAM20 8.8
SIT protein 8.8
PKC2 8.8
GNA14 8.7
TRPC7 8.7
PIP kinase 8.6
Bst1 8.6
PLCD1 8.6
phosphatidic acid phosphohydrolase 8.6
phospholipase D 8.6
Aminopeptidase P 8.6
DAGK 8.5
ovarian cancer G protein-coupled receptor 1 8.5
PLCgamma1 8.5
SESTD1 8.4
DFNB22 8.4
CHST10 8.4
B cell linker protein 8.4
Ubiquitin-protein ligase 8.4
m3 muscarinic acetylcholine receptor 8.4
more...
Disease
DFNB22 8.4
IgA2 deficiency 8.2
INAD 7.7
AGS4 7.6
Chronic apical periodontitis 7.4
Acute hyperkalemia 7.4
gas gangrene 7.4
Diarrhea-associated hemolytic uremic syndrome 7.3
pertussis 6.9
Acute esophagitis 6.8
histiocytic leukemia 6.6
EL3 6.3
Necrotic enteritis 6.3
Neutrophil dysfunction 6.2
MF4 6.2
Staphylococcal sepsis 5.9
Mucolipidosis 5.9
FHM2 5.9
AOA2 5.8
Familial hypocalciuric hypercalcemia 5.7
leukonychia 5.6
Staphylococcus aureus pneumonia 5.6
Riehl's melanosis 5.5
Struck 5.5
AD6 5.5
EL2 5.4
CG3 5.3
HHP 5.3
RGS 5.3
athymia 5.2
Erythroleukemia 5.1
VED 5.1
gastrointestinal reflux 5.1
paroxysmal nocturnal hemoglobinuria 5.0
IgG4 deficiency 5.0
LAD2 5.0
sCJD 5.0
AKV 4.9
TGCT 4.9
Dressler 4.9
NPS 4.9
LGMD2C 4.8
ML III 4.7
alcohol impairment 4.6
Scott syndrome 4.6
osteoblastic osteosarcoma 4.6
GH-secreting pituitary adenoma 4.6
placental disorders 4.6
PAF 4.5
nail disease 4.5
disorders of calcium metabolism 4.5
OHS 4.5
BCM 4.5
TD1 4.4
cholera 4.4
Staphylococcus aureus septicemia 4.3
Enzyme inhibition 4.3
MODY1 4.3
LEL 4.3
myxosarcoma 4.3
astrocytoma 4.3
Lowe syndrome 4.3
EL1 4.2
extrahepatic bile duct cancer 4.2
LPI 4.2
Opioid use disorder 4.2
monocytic leukemia 4.2
nasal infection 4.2
Myrmecia 4.2
Ruvalcaba syndrome 4.2
Irritant contact dermatitis 4.1
HDL3 4.1
Staphylococcus aureus infection 4.1
hypophosphatasia 4.1
X-linked agammaglobulinemia 4.1
luteoma 4.1
IgG2 deficiency 4.1
clostridial infection 4.0
genetic hypertension 4.0
TEC 4.0
more...
Symptom
Easy bruising 7.3
rundown 5.5
Inflammatory pain 4.5
bitter taste 4.3
male subfertility 3.7
blackout 3.5
impaired motor coordination 3.2
fasciculation 2.4
hyperacusis 2.3
twitching 1.8
Anoxia 1.6
dry eye 1.4
clonus 1.2
starvation 1.2
despair 1.1
rigors 1.1
muscle cramps 0.9
acute pain 0.8
emaciation 0.7
microbial colonization 0.7
muscle rigidity 0.7
urinary frequency 0.6
hypertonia 0.5
Neuropathic pain 0.3
spasm 0.2
HSA 0.2
skin damage 0.2
ophthalmoplegia 0.0
hypocapnia 0.0
hyperoxia -0.0
memory loss -0.1
analgesia -0.1
cachexia -0.1
sneezing -0.1
exhaustion -0.2
pain -0.2
hypercapnia -0.2
ataxia -0.2
collapse -0.2
diarrhea -0.3
respiratory distress -0.3
functional recovery -0.4
rhinorrhea -0.4
seizures -0.4
acute stress -0.4
erythema -0.6
anorexia -0.7
hypothermia -0.7
spasticity -0.9
cerebellar ataxia -1.1
apathy -1.2
regurgitation -1.3
chills -1.3
syncope -1.4
splenomegaly -1.5
paresthesia -1.5
acidity -1.6
constipation -1.6
numbness -1.6
insomnia -1.6
ENT -1.6
thinning -1.7
paresis -1.8
hypotonia -1.8
agitation -1.8
tremor -1.8
flushing -1.9
myalgia -1.9
tinnitus -1.9
vertigo -2.1
anesthesia -2.4
weakness -2.5
dizziness -2.5
sleepiness -2.9
overweight -2.9
chest pain -3.3
angina -3.6
discomfort -3.7
nausea -3.8
cough -3.8
more...
Drug
Parotin 8.8
Propagermanium 7.8
Ticlid 7.3
Sarpogrelate hydrochloride 7.1
Lisofylline 7.0
Tiotidine 6.8
Piriprost 6.7
Quisqualate 6.5
Myo-Inositol 6.4
Brij 96 6.3
Bitrex 6.2
Cevimeline 6.1
Arachidonic Acid 6.1
Ticlopidine hydrochloride 6.1
2'-Deoxyadenosine 6.1
Fenoldopam 6.0
Bifonazole 6.0
Tenidap 6.0
Neamine 5.7
K-252a 5.5
Avilamycin 5.5
MT6 5.4
Olomoucine 5.3
Cilastatin 5.3
PDGF B-chain 5.3
ETA 5.2
Darifenacin 5.2
Platelet Activating Factor 5.2
Pronase 5.1
Angiotensin II 5.1
RPH 5.0
4-Hydroxytamoxifen 5.0
Cinnarizine 4.9
Ibudilast 4.9
Fluphenazine 4.8
Forskolin 4.8
Butaprost 4.8
GHRP 4.8
Sulprostone 4.8
Nafcillin 4.8
Zoloft 4.7
Levamisol 4.6
Flurazepam 4.6
RBT 4.6
Palmitoyl 4.6
Atosiban 4.5
Histamine 4.5
Propentofylline 4.4
Cicletanine 4.4
Phosphatidylserine 4.4
Pyridoxal 4.3
Iloprost 4.3
Trifluoperazine 4.3
Agomelatine 4.2
Lipidex 4.2
Gramicidin 4.2
Tween 40 4.2
Doyle 4.1
Ancrod 4.1
Cinacalcet 4.1
beta-Galactosidase 4.0
Terlipressin 4.0
Terlipressin 4.0
Dantrolene sodium 4.0
Adenosine triphosphate 3.9
Sesamol 3.9
CaCl2 3.9
CaCl2 3.9
CDP 3.9
CaCl2 3.9
Plavix 3.8
Deoxyadenosine 3.8
uPA 3.8
Compound 15 3.8
Nebivolol 3.7
PTH 3.7
KAN 3.6
Rolipram 3.6
Streptokinase 3.6
Secretin 3.6
more...
Enzyme
inositol-tetrakisphosphate 1-kinase 10.8
phosphatidylinositol phospholipase A2 10.8
phospholipase C 10.8
EC 3.1.3.57 9.8
PI-PLC 8.9
phospholipase D 8.6
GPI-specific phospholipase C 8.5
UDP-glucose:dolichol phosphate glucosyltransferase 8.4
GPI-PLD 8.3
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 8.2
Ins(1,4,5)P3 3-kinase 8.0
diacylglycerol kinase 8.0
phosphatidylinositol phospholipase C 8.0
PIP kinase 8.0
phosphoinositide 5-phosphatase 7.9
phosphatidylinositol 4-kinase 7.5
phospholipase A1 7.3
ceramide cholinephosphotransferase 7.3
phospholipase A2 7.2
aureolysin 7.2
glycerophosphocholine cholinephosphodiesterase 7.1
sphingomyelin synthase 7.0
protein kinase C 7.0
inositol polyphosphate kinase 6.9
phosphatidylinositol synthase 6.8
retinol isomerase 6.8
aminopeptidase P 6.8
phosphatidylinositol 3-phosphate 5-kinase 6.8
phosphocholine cytidylyltransferase 6.6
leishmanolysin 6.5
choline kinase 6.5
CDP-diacylglycerol synthase 6.5
ethanolamine kinase 6.4
acylcarnitine hydrolase 6.4
monoacylglycerol lipase 6.3
arachidonoyl-CoA synthetase 6.3
galactolipase 6.3
alkylglycerol monooxygenase 6.2
PNAE 6.2
sphingosine kinase 6.2
phospholipid methyltransferase 6.1
PGE2-9-ketoreductase 6.1
inosine triphosphatase 6.1
neuropathy target esterase 6.0
PLP phosphatase 6.0
8-lipoxygenase 6.0
adenylate cyclase 6.0
neutral sphingomyelinase 6.0
lysophosphatidylcholine acyltransferase 5.9
glycerol 3-phosphatase 5.8
trehalose phosphate synthase 5.8
NAD glycohydrolase 5.8
ADP-ribosyltransferase 5.8
methylmalonate-semialdehyde dehydrogenase 5.8
GSase 5.8
phosphatidylinositol 3-kinase 5.8
oligopeptidase B 5.8
phosphoethanolamine cytidylyltransferase 5.8
ADP-ribosyltransferase 5.7
GRK2 5.7
phosphatidylglycerophosphate synthase 5.7
phosphoinositide 3-kinase 5.6
12-oxophytodienoate reductase 5.6
glutathione-insulin transhydrogenase 5.6
myosin light chain kinase 5.6
ceramidase 5.5
GRK5 5.5
phosphoamidase 5.5
mannosylphosphoryldolichol synthase 5.5
nicotinamide adenine dinucleotide glycohydrolase 5.4
GDP-mannose dehydrogenase 5.4
apyrase 5.4
2',3'-cyclic nucleotide phosphohydrolase 5.4
tubulin carboxypeptidase 5.4
phosphatidate phosphatase 5.3
endomannosidase 5.3
prepilin peptidase 5.3
lipoprotein lipase 5.3
PTPase 5.3
dienelactone hydrolase 5.3
more...
Compound
N,N'-dihydroxyurea 10.8
1-(chloromethyl)naphthalene 10.8
C10H13NO2 9.8
Inositol 1,2-cyclic phosphate 9.8
Substance B 9.8
1,1,1-trifluoro-2-butanone 9.8
2,5-pyrrolidinedione 9.4
1H-pyrrole-2,5-dione 9.3
2,4,6-trimethylbenzenesulfonamide 9.2
inositol 1,4-bisphosphate 8.8
1,2,4-trimethylcyclohexane 8.8
1,2,4-trimethylcyclohexane 8.8
Inositol phosphate 8.6
Inositol 1,3,4-trisphosphate 8.5
Pseudoisocyanine 8.4
Dicumyl peroxide 8.4
Lophotoxin 8.3
Ins(1,4,5)P3 8.3
Succinimide 8.2
Methyltryptamine 8.2
Norbormide 8.2
Norbormide 8.2
piperidine oxalate 8.2
Neomycin sulfate 8.1
Neomycin sulfate 7.9
isobutyl propionate 7.9
GF 109203X 7.8
Neomycin 7.8
Methyl pyruvate 7.8
Gallein 7.7
Phosphatidylinositol 7.7
2-aminoethyl diphenylborinate 7.7
2-aminoethyl diphenylborinate 7.7
myo-inositol 1-phosphate 7.6
Propagermanium 7.6
3-methyl-9H-carbazole 7.6
Gallein 7.6
G11 7.5
K-38 7.4
propanoyl chloride 7.4
Diospyrin 7.3
Protriptyline 7.2
8-(diethylamino)octyl 3,4,5-trimethoxybenzoate 7.2
Inositol 7.1
3,4-D 7.1
Isoferulic acid 7.1
Phorbol-12,13-dibutyrate 7.1
2,2-dichloroethanol 7.1
DAG 7.0
Neomycin B 6.9
Ribostamycin 6.8
Neamine 6.8
Sangivamycin 6.8
3,4,5-trimethoxybenzoic acid 6.8
Carbachol 6.8
4-methyl-1,2,3-thiadiazole 6.8
beta-Eudesmol 6.7
Norathyriol 6.7
Bistris 6.7
Econazole 6.7
Humulone 6.7
Safrole 6.6
PPADS 6.6
1H-pyrrole 6.6
1H-pyrrole 6.6
Thapsigargin 6.6
Scytalone 6.6
9-octadecenyl 6.6
4-methoxybenzenesulfonamide 6.6
9-octadecenyl 6.6
Bistris 6.6
2-methylpiperazine 6.5
2-oxopropanal 6.5
8-iso-PGE2 6.5
Taurodeoxycholic acid 6.5
1,8-octanediamine 6.5
Amarogentin 6.5
Trimetoquinol 6.5
1-methylanthracene 6.5
Econazole 6.5
more...