| Enzyme |
| phospholipase C | 18461 | |
| protein kinase C | 3614 | |
| phospholipase A2 | 1222 | |
| protein kinase | 1182 | |
| mitogen-activated protein kinase | 1048 | |
| phospholipase D | 829 | |
| adenylate cyclase | 710 | |
| thrombin | 561 | |
| ERK | 353 | |
| phosphatidylinositol 3-kinase | 349 | |
| ATPase | 336 | |
| trypsin | 277 | |
| alkaline phosphatase | 254 | |
| lipase | 244 | |
| focal adhesion kinase | 227 | |
| MEK | 208 | |
| phosphodiesterase | 178 | |
| phosphoinositide 3-kinase | 169 | |
| lipoprotein lipase | 161 | |
| PI-PLC | 153 | |
| neuraminidase | 150 | |
| calcineurin | 150 | |
| diacylglycerol kinase | 145 | |
| lipoxygenase | 136 | |
| guanylate cyclase | 123 | |
| NADPH oxidase | 107 | |
| NADPH oxidase | 100 | |
| acetylcholinesterase | 99 | |
| AMPK | 98 | |
| luciferase | 81 | |
| CaMKII | 79 | |
| myosin light chain kinase | 74 | |
| NO synthase | 73 | |
| phosphatidylinositol 4-kinase | 73 | |
| acid phosphatase | 73 | |
| elastase | 64 | |
| collagenase | 61 | |
| caspase-3 | 60 | |
| peroxidase | 57 | |
| superoxide dismutase | 56 | |
| glutathione S-transferase | 54 | |
| 5'-nucleotidase | 54 | |
| urokinase-type plasminogen activator | 54 | |
| reverse transcriptase | 50 | |
| RNase | 50 | |
| lactate dehydrogenase | 49 | |
| catalase | 46 | |
| RNase | 46 | |
| chymotrypsin | 45 | |
| PARP | 43 | |
| MAP | 40 | |
| neuropathy target esterase | 40 | |
| renin | 39 | |
| papain | 39 | |
| phospholipase A1 | 37 | |
| apyrase | 37 | |
| CPT | 36 | |
| PKG | 35 | |
| DNase | 35 | |
| hyaluronidase | 35 | |
| ADP-ribosyltransferase | 34 | |
| thromboplastin | 32 | |
| monoacylglycerol lipase | 32 | |
| ADP-ribosyltransferase | 31 | |
| sphingosine kinase | 31 | |
| proteinase K | 31 | |
| transglutaminase | 30 | |
| GRK5 | 29 | |
| PIP kinase | 29 | |
| hexosaminidase | 28 | |
| creatine kinase | 28 | |
| aequorin | 28 | |
| plasmin | 28 | |
| MDP | 27 | |
| protein phosphatase 2A | 27 | |
| RNA polymerase | 27 | |
| AMP-activated protein kinase | 27 | |
| hyaluronidase | 26 | |
| phosphorylase | 26 | |
| GRK2 | 26 | |
| sialidase | 25 | |
| proteasome | 25 | |
| neutral sphingomyelinase | 24 | |
| ornithine decarboxylase | 23 | |
| choline kinase | 23 | |
| adenosine deaminase | 23 | |
| ribonuclease | 23 | |
| PTPase | 23 | |
| ribonuclease | 23 | |
| adenosine deaminase | 23 | |
| lysozyme | 22 | |
| CD13 | 21 | |
| tyrosine hydroxylase | 20 | |
| beta-galactosidase | 20 | |
| IKK | 20 | |
| GPI-specific phospholipase C | 18 | |
| sphingomyelin synthase | 18 | |
| PNGase F | 18 | |
| cGMP phosphodiesterase | 18 | |
| PDE | 16 | |
| calcium pump | 16 | |
| CPT | 16 | |
| beta-glucuronidase | 16 | |
| cholinesterase | 15 | |
| CPT | 15 | |
| xanthine oxidase | 15 | |
| ACE | 15 | |
| aminopeptidase P | 14 | |
| transcriptase | 14 | |
| GSK | 14 | |
| hormone-sensitive lipase | 14 | |
| NOS | 14 | |
| NAD glycohydrolase | 14 | |
| phosphatidylinositol phospholipase C | 14 | |
| chondroitinase | 13 | |
| carbonic anhydrase | 13 | |
| CD10 | 13 | |
| gamma-glutamyl transpeptidase | 13 | |
| chondroitinase | 13 | |
| deaminase | 12 | |
| endoglycosidase H | 12 | |
| p-nitrophenylphosphatase | 12 | |
| caspase-8 | 12 | |
| phosphocholine cytidylyltransferase | 12 | |
| Ins(1,4,5)P3 3-kinase | 11 | |
| cholesterol oxidase | 11 | |
| triphosphatase | 11 | |
| ATP synthase | 11 | |
| caspase-9 | 11 | |
| deoxyribonuclease | 11 | |
| heparinase | 11 | |
| deoxyribonuclease | 11 | |
| MEKK1 | 10 | |
| CPR | 10 | |
| diaphorase | 10 | |
| alpha-amylase | 10 | |
| MMP-3 | 10 | |
| APC | 10 | |
| MMP | 9 | |
| ACS | 9 | |
| AMPK | 9 | |
| PDK1 | 9 | |
| chitinase | 9 | |
| lysophosphatidylcholine acyltransferase | 9 | |
| chloramphenicol acetyltransferase | 9 | |
| 12-lipoxygenase | 9 | |
| beta-lactamase | 9 | |
| ceramidase | 9 | |
| DNA polymerase | 9 | |
| alpha-mannosidase | 9 | |
| neutrophil elastase | 8 | |
| cathepsin G | 8 | |
| phosphoinositide 5-phosphatase | 8 | |
| acyl-CoA synthetase | 8 | |
| tryptase | 8 | |
| tissue plasminogen activator | 8 | |
| lysin | 8 | |
| pyruvate dehydrogenase | 8 | |
| leucine aminopeptidase | 8 | |
| dipeptidyl peptidase IV | 8 | |
| MIP | 8 | |
| pyruvate dehydrogenase | 8 | |
| inositol phosphatase | 7 | |
| GPI-PLD | 7 | |
| thermolysin | 7 | |
| pyruvate dehydrogenase | 7 | |
| xylanase | 7 | |
| pepsin | 7 | |
| beta-glucosidase | 7 | |
| choline acetyltransferase | 7 | |
| glucose-6-phosphatase | 7 | |
| m-calpain | 7 | |
| bromelain | 7 | |
| trehalase | 7 | |
| xylanase | 7 | |
| kallikrein | 7 | |
| glutathione reductase | 7 | |
| glyceraldehyde-3-phosphate dehydrogenase | 7 | |
| C3 convertase | 7 | |
| phosphatidylinositol synthase | 7 | |
| choline oxidase | 7 | |
| thymidine kinase | 7 | |
| beta-glucosidase | 6 | |
| hexokinase | 6 | |
| rhodopsin kinase | 6 | |
| glutamine synthetase | 6 | |
| monoamine oxidase | 6 | |
| phosphoenolpyruvate carboxykinase | 6 | |
| alpha-glucosidase | 6 | |
| P-glycoprotein | 6 | |
| adenylate kinase | 6 | |
| glutathione peroxidase | 6 | |
| phosphoenolpyruvate carboxykinase | 6 | |
| carboxylesterase | 6 | |
| phosphoenolpyruvate carboxykinase | 6 | |
| C3 convertase | 6 | |
| caspase-1 | 6 | |
| subtilisin | 6 | |
| inosine triphosphatase | 6 | |
| 15-lipoxygenase | 5 | |
| cruzipain | 5 | |
| acyl-CoA synthetase | 5 | |
| mu-calpain | 5 | |
| CDP-diacylglycerol synthase | 5 | |
| phosphatidate phosphatase | 5 | |
| PAT | 5 | |
| ADPase | 5 | |
| CPM | 5 | |
| heme oxygenase | 5 | |
| cholesterol esterase | 5 | |
| galactose oxidase | 5 | |
| alcohol dehydrogenase | 5 | |
| aldolase | 5 | |
| cdc2 | 5 | |
| glucokinase | 5 | |
| PCP | 5 | |
| furin | 5 | |
| acrosin | 5 | |
| cathepsin B | 5 | |
| glyceraldehyde-3-phosphate dehydrogenase | 4 | |
| glyceraldehyde-3-phosphate dehydrogenase | 4 | |
| dopamine beta-hydroxylase | 4 | |
| lysyl endopeptidase | 4 | |
| aldose reductase | 4 | |
| prostaglandin synthetase | 4 | |
| Mg2+-ATPase | 4 | |
| cathepsin D | 4 | |
| diacylglycerol acyltransferase | 4 | |
| glyceraldehyde-3-phosphate dehydrogenase | 4 | |
| asparaginase | 4 | |
| topoisomerase | 4 | |
| ricin | 4 | |
| alanine aminotransferase | 4 | |
| glyceraldehyde-3-phosphate dehydrogenase | 4 | |
| histidine decarboxylase | 4 | |
| phosphoenolpyruvate carboxylase | 4 | |
| glycerol-3-phosphate dehydrogenase | 4 | |
| acylase | 4 | |
| phospholipid methyltransferase | 4 | |
| aureolysin | 4 | |
| phytase | 4 | |
| nucleotidase | 4 | |
| cholesterol acyltransferase | 4 | |
| glucose oxidase | 4 | |
| carboxypeptidase Y | 4 | |
| glycerol-3-phosphate dehydrogenase | 4 | |
| leishmanolysin | 4 | |
| pyruvate kinase | 4 | |
| oligopeptidase B | 4 | |
| prolyl hydroxylase | 4 | |
| TAT | 4 | |
| peroxiredoxin | 4 | |
| alpha-L-fucosidase | 4 | |
| phytase | 4 | |
| urease | 3 | |
| BIS | 3 | |
| lysophospholipase D | 3 | |
| acetyl-CoA carboxylase | 3 | |
| protein disulfide-isomerase | 3 | |
| urease | 3 | |
| sulfatase | 3 | |
| prostacyclin synthase | 3 | |
| thromboxane synthase | 3 | |
| clostripain | 3 | |
| cathepsin H | 3 | |
| botulinum neurotoxin | 3 | |
| glycerophosphate acyltransferase | 3 | |
| ADH | 3 | |
| beta-secretase | 3 | |
| pectinase | 3 | |
| SPS | 3 | |
| topoisomerase | 3 | |
| UDP-glucuronosyltransferase | 3 | |
| HSD | 3 | |
| TOR | 3 | |
| 3-hydroxy-3-methylglutaryl-CoA reductase | 3 | |
| cathepsin K | 3 | |
| ethanolamine kinase | 3 | |
| glucose-6-phosphate dehydrogenase | 3 | |
| nitrate reductase | 3 | |
| glutamate decarboxylase | 3 | |
| nitrate reductase | 3 | |
| phosphatidylglycerophosphate synthase | 3 | |
| SPT | 3 | |
| thioredoxin reductase | 3 | |
| SPT | 3 | |
| nitrate reductase | 3 | |
| alanine aminopeptidase | 3 | |
| caspase-7 | 3 | |
| lecithin:cholesterol acyltransferase | 3 | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | 3 | |
| inositol polyphosphate kinase | 3 | |
| carboxypeptidase E | 3 | |
| succinate dehydrogenase | 3 | |
| TSA | 3 | |
| nitrate reductase | 3 | |
| SPC | 3 | |
| nitrate reductase | 3 | |
| nitrate reductase | 3 | |
| caspase-7 | 3 | |
| cellulose synthase | 3 | |
| S1 nuclease | 3 | |
| endonuclease | 3 | |
| tissue kallikrein | 2 | |
| arachidonate 5-lipoxygenase | 2 | |
| CNPase | 2 | |
| glucosylceramide synthase | 2 | |
| EPT | 2 | |
| cytochrome P-450scc | 2 | |
| tryptophan hydroxylase | 2 | |
| firefly luciferase | 2 | |
| sucrase-isomaltase | 2 | |
| PHD | 2 | |
| endo-beta-galactosidase | 2 | |
| prostasin | 2 | |
| endo-beta-galactosidase | 2 | |
| IMP dehydrogenase | 2 | |
| interstitial collagenase | 2 | |
| sialyltransferase | 2 | |
| BAT | 2 | |
| mannosidase II | 2 | |
| sialyltransferase | 2 | |
| sialyltransferase | 2 | |
| ficin | 2 | |
| lysostaphin | 2 | |
| alpha-L-fucosidase | 2 | |
| prepilin peptidase | 2 | |
| argininosuccinate lyase | 2 | |
| dihydrofolate reductase | 2 | |
| Rex | 2 | |
| venom phosphodiesterase | 2 | |
| arylalkylamine N-acetyltransferase | 2 | |
| alpha-galactosidase | 2 | |
| NAT | 2 | |
| chitin synthase | 2 | |
| invertase | 2 | |
| cellulase | 2 | |
| myosin ATPase | 2 | |
| alpha-L-fucosidase | 2 | |
| aspartate aminotransferase | 2 | |
| kinesin | 2 | |
| sucrase | 2 | |
| complex I | 2 | |
| SOR | 2 | |
| glutaminase | 2 | |
| malate dehydrogenase | 2 | |
| argininosuccinate synthetase | 2 | |
| CGT | 2 | |
| enolase | 2 | |
| deoxycytidine kinase | 2 | |
| peptidyl-prolyl cis-trans isomerase | 2 | |
| N-acetyltransferase | 2 | |
| pyruvate:ferredoxin oxidoreductase | 2 | |
| DOPA decarboxylase | 2 | |
| matrix metalloproteinase 2 | 2 | |
| MsrB | 2 | |
| phosphatidylserine synthase | 2 | |
| galactolipase | 2 | |
| glutathione-insulin transhydrogenase | 2 | |
| BBE | 2 | |
| S-adenosylmethionine decarboxylase | 2 | |
| glycerol 3-phosphate dehydrogenase | 2 | |
| sulfiredoxin | 2 | |
| cytochrome oxidase | 2 | |
| glycoprotease | 2 | |
| phosphofructokinase | 2 | |
| ceruloplasmin | 2 | |
| ceramide kinase | 2 | |
| aminopeptidase A | 2 | |
| MDR | 2 | |
| ubiquitin-protein ligase | 2 | |
| matrix metalloproteinase 9 | 2 | |
| carboxypeptidase A | 2 | |
| glycerol kinase | 2 | |
| tyrosinase | 2 | |
| PGE2-9-ketoreductase | 2 | |
| phosphoglycerate kinase | 2 | |
| enterokinase | 2 | |
| phosphatidylethanolamine N-methyltransferase | 2 | |
| ribonucleotide reductase | 2 | |
| GAR | 2 | |
| phenylethanolamine N-methyltransferase | 2 | |
| ribonucleotide reductase | 2 | |
| inositol 3-kinase | 2 | |
| p100 | 2 | |
| GSase | 2 | |
| PAL | 2 | |
| DCF | 2 | |
| p80 | 1 | |
| dienelactone hydrolase | 1 | |
| thymidylate synthase | 1 | |
| PAH | 1 | |
| nucleoside phosphotransferase | 1 | |
| endoproteinase Glu-C | 1 | |
| prolyl endopeptidase | 1 | |
| 2',3'-cyclic nucleotide phosphohydrolase | 1 | |
| catechol O-methyltransferase | 1 | |
| 11beta-hydroxysteroid dehydrogenase | 1 | |
| N-acetylglucosaminyltransferase I | 1 | |
| acylglycerol kinase | 1 | |
| phosphatidylinositol phospholipase A2 | 1 | |
| glycerophosphocholine cholinephosphodiesterase | 1 | |
| chymase | 1 | |
| aldehyde dehydrogenase | 1 | |
| sphingomyelinase D | 1 | |
| 8-lipoxygenase | 1 | |
| UDP-glucosyltransferase | 1 | |
| C3b inactivator | 1 | |
| 1-acylglycerol-3-phosphate O-acyltransferase | 1 | |
| mannosylphosphoryldolichol synthase | 1 | |
| phosphorylase kinase | 1 | |
| glycerophosphodiester phosphodiesterase | 1 | |
| ACC synthase | 1 | |
| NCED | 1 | |
| succinic dehydrogenase | 1 | |
| indoleamine 2,3-dioxygenase | 1 | |
| E-2 | 1 | |
| PGE2 isomerase | 1 | |
| nicotinamide phosphoribosyltransferase | 1 | |
| cytidine deaminase | 1 | |
| arylsulfatase | 1 | |
| alkylglycerol monooxygenase | 1 | |
| AMP deaminase | 1 | |
| ancrod | 1 | |
| 5alpha-reductase | 1 | |
| proteinase-3 | 1 | |
| prostate-specific antigen | 1 | |
| MPP | 1 | |
| prostaglandin F synthase | 1 | |
| granzyme B | 1 | |
| factor C | 1 | |
| CAD | 1 | |
| transcarboxylase | 1 | |
| ornithine transcarbamylase | 1 | |
| UDP-glucose:dolichol phosphate glucosyltransferase | 1 | |
| CAD | 1 | |
| ClpP | 1 | |
| polyphosphatase | 1 | |
| RPH | 1 | |
| VIP1 | 1 | |
| nucleoside diphosphokinase | 1 | |
| PRPP synthetase | 1 | |
| heparitinase I | 1 | |
| ACC oxidase | 1 | |
| tetanus neurotoxin | 1 | |
| phosphoethanolamine cytidylyltransferase | 1 | |
| dextranase | 1 | |
| serine racemase | 1 | |
| galactinol synthase | 1 | |
| endo-alpha-N-acetylgalactosaminidase | 1 | |
| methylmalonate-semialdehyde dehydrogenase | 1 | |
| LipB | 1 | |
| mannosidase I | 1 | |
| 3-hydroxyacyl-CoA dehydrogenase | 1 | |
| endothelin-converting enzyme | 1 | |
| PAF acetyltransferase | 1 | |
| jararhagin | 1 | |
| aldehyde dehydrogenase | 1 | |
| diamine oxidase | 1 | |
| calpain 3 | 1 | |
| chalcone synthase | 1 | |
| penicillin binding protein | 1 | |
| endoglycoceramidase | 1 | |
| sucrose synthase | 1 | |
| endomannosidase | 1 | |
| ATP diphosphohydrolase | 1 | |
| PNAE | 1 | |
| nucleotide pyrophosphatase | 1 | |
| LasR | 1 | |
| galactosyltransferase I | 1 | |
| farnesyltransferase | 1 | |
| H,K-ATPase | 1 | |
| aldehyde dehydrogenase | 1 | |
| farnesyltransferase | 1 | |
| Pla | 1 | |
| formate dehydrogenase | 1 | |
| cysteine synthase | 1 | |
| cystathionine gamma-synthase | 1 | |
| beta-amylase | 1 | |
| alcohol acetyltransferase | 1 | |
| transglucosylase | 1 | |
| demethylase | 1 | |
| N-acetylglucosaminyltransferase | 1 | |
| protein farnesyltransferase | 1 | |
| mannanase | 1 | |
| myo-inositol-1-phosphate synthase | 1 | |
| acyl-CoA thioesterase | 1 | |
| sortase A | 1 | |
| betaine aldehyde dehydrogenase | 1 | |
| beta-1,3-glucanase | 1 | |
| IgA1 protease | 1 | |
| formate dehydrogenase | 1 | |
| chaperonin | 1 | |
| neurolysin | 1 | |
| beta-hydroxybutyrate dehydrogenase | 1 | |
| dynamin GTPase | 1 | |
| NADH dehydrogenase | 1 | |
| LIS | 1 | |
| PAL | 1 | |
| 3-hydroxyacyl-CoA dehydrogenase | 1 | |
| meprin | 1 | |
| pyruvate oxidase | 1 | |
| beta-1,3-glucanase | 1 | |
| oxalate oxidase | 1 | |
| retinol isomerase | 1 | |
| pyruvate oxidase | 1 | |
| halogenase | 1 | |
| ceramide cholinephosphotransferase | 1 | |
| isocitrate dehydrogenase | 1 | |
| 6-phosphogluconate dehydrogenase | 1 | |
| cystathionine beta-synthase | 1 | |
| paraoxonase | 1 | |
| 6-phosphogluconate dehydrogenase | 1 | |
| haloalkane dehalogenase | 1 | |
| levansucrase | 1 | |
| chymopapain | 1 | |
| 3beta-hydroxysteroid dehydrogenase | 1 | |
| LDT | 1 | |
| phosphoamidase | 1 | |
| lysine decarboxylase | 1 | |
| tyrosine aminotransferase | 1 | |
| aldehyde dehydrogenase | 1 | |
| glycerol dehydrogenase | 1 | |
| diaphorase | 1 | |
| alpha-sarcin | 1 | |
| STR | 1 | |
| aldehyde dehydrogenase | 1 | |
| glycerol dehydrogenase | 1 | |
| Lys4 | 1 | |
| arachidonoyl-CoA synthetase | 1 | |
| MsrA | 1 | |
| methionine sulfoxide reductase | 1 | |
| 3-hydroxy-3-methylglutaryl coenzyme A reductase | 1 | |
| nicotinamide adenine dinucleotide glycohydrolase | 1 | |
| aromatic L-amino acid decarboxylase | 1 | |
| LPL | 1 | |
| acylcarnitine hydrolase | 1 | |
| type 1 protein phosphatase | 1 | |
| soluble epoxide hydrolase | 1 | |
| phosphoglycolate phosphatase | 1 | |
| CAD | 1 | |
| iodothyronine 5'-deiodinase | 1 | |
| glycerol 3-phosphatase | 1 | |
| phosphatidylserine decarboxylase | 1 | |
| dolichol kinase | 1 | |
| BAL | 1 | |
| 5alpha-reductase | 1 | |
| inositol-tetrakisphosphate 1-kinase | 1 | |
| citrate synthase | 1 | |
| HMG-CoA synthase | 1 | |
| endoproteinase Asp-N | 1 | |
| phosphatidylinositol 3-phosphate 5-kinase | 1 | |
| carnosinase | 1 | |
| pyruvate dehydrogenase phosphatase | 1 | |
| calpain 3 | 1 | |
| cathepsin C | 1 | |
| CDH | 1 | |
| neutrophil collagenase | 1 | |
| xylulokinase | 1 | |
| DAP II | 1 | |
| pantetheinase | 1 | |
| phospholipid:diacylglycerol acyltransferase | 1 | |
| LipA | 1 | |
| 12-oxophytodienoate reductase | 1 | |
| carboxypeptidase D | 1 | |
| cellulose synthase | 1 | |
| arylsulfatase A | 1 | |
| EC 3.1.3.57 | 1 | |
| laccase | 1 | |
| myo-inositol oxygenase | 1 | |
| formate dehydrogenase | 1 | |
| histidine kinase | 1 | |
| paraoxonase | 1 | |
| tubulin carboxypeptidase | 1 | |
| trehalose phosphate synthase | 1 | |
| ascorbate oxidase | 1 | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | 1 | |
| PME | 1 | |
| histone acetyltransferase | 1 | |
| carboxypeptidase B | 1 | |
| NQO2 | 1 | |
| CPN | 1 | |
| MGDG synthase | 1 | |
| DMT | 1 | |
| ascorbate peroxidase | 1 | |
| phosphoglucose isomerase | 1 | |
| arginase | 1 | |
| NPL | 1 | |
| PAM | 1 | |
| PLP phosphatase | 1 | |
| phospholipid hydroperoxide glutathione peroxidase | 1 | |
| GDP-mannose dehydrogenase | 1 | |
| pyroglutamate aminopeptidase | 1 | |
| pyroglutamyl peptidase II | 1 | |
| peptidylarginine deiminase | 1 | |
| 1-hydroxylase | 1 | |
| thyroid peroxidase | 1 | |
| chymopapain | 1 | |
| RGP | 1 | |
| MCS | 1 | |
| PRE | 1 | |
| cystathionine gamma-lyase | 1 | |
| sorbitol dehydrogenase | 1 | |
| acetylserotonin O-methyltransferase | 1 | |