Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.3 (phospholipase C)
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Human Gene/Protein
mitochondrial cytochrome c oxidase subunit Va 10.8
protein kinase C and casein kinase substrate in neurons 3 10.8
myotubularin related protein 7 10.8
p122-RhoGAP 10.8
Type I phosphoinositide 3-kinase 10.8
SPINT2 protein 10.8
PLC-III 10.8
Parkinson disease (autosomal recessive, juvenile) 2, parkin 10.8
PLC-IV 10.8
Calmodulin-binding transcription activator 2 10.8
phosphatidylinositol-specific 10.7
PLC-II 10.5
phosphoinositide-specific 10.4
PLCeta2 10.3
PLC1 10.2
Phosphoinositide phospholipase C 10.2
PLCzeta 10.2
GTP-binding protein Rab3A 10.0
PLC-I 10.0
P2X purinoceptor 2 9.8
ERP60 9.8
PLCH1 9.8
phospholipase A2, group IVB 9.8
transient receptor potential cation channel, subfamily M, member 4 9.8
enkurin 9.8
Gq class 9.5
PI-PLC 9.5
WBP2NL 9.3
PLCB3 9.3
hGRP 9.3
Phospholipase C 9.3
Galpha14 9.3
MAFF protein 9.2
Mono(ADP-ribosyl)transferase 9.2
Bardet-Biedl syndrome 5 9.2
CD48 protein 9.2
VHCH1 9.2
Enkurin 9.2
PLCE 9.2
PRLHR 9.2
more...
Disease
DFNB22 8.4
IgA2 deficiency 8.2
INAD 7.7
AGS4 7.6
Acute hyperkalemia 7.4
Chronic apical periodontitis 7.4
gas gangrene 7.4
Diarrhea-associated hemolytic uremic syndrome 7.3
pertussis 6.9
Acute esophagitis 6.8
histiocytic leukemia 6.6
EL3 6.3
Necrotic enteritis 6.3
Neutrophil dysfunction 6.2
MF4 6.2
Mucolipidosis 5.9
Staphylococcal sepsis 5.9
FHM2 5.9
AOA2 5.8
Familial hypocalciuric hypercalcemia 5.7
leukonychia 5.6
Staphylococcus aureus pneumonia 5.6
Riehl's melanosis 5.5
Struck 5.5
AD6 5.5
EL2 5.4
HHP 5.3
CG3 5.3
RGS 5.3
athymia 5.2
Erythroleukemia 5.1
VED 5.1
gastrointestinal reflux 5.1
paroxysmal nocturnal hemoglobinuria 5.0
LAD2 5.0
IgG4 deficiency 5.0
sCJD 5.0
AKV 4.9
TGCT 4.9
Dressler 4.9
more...
Symptom
Easy bruising 7.3
rundown 5.5
Inflammatory pain 4.5
bitter taste 4.3
male subfertility 3.7
blackout 3.5
impaired motor coordination 3.2
fasciculation 2.4
hyperacusis 2.3
twitching 1.8
Anoxia 1.6
dry eye 1.4
clonus 1.2
starvation 1.2
despair 1.1
rigors 1.1
muscle cramps 0.9
acute pain 0.8
emaciation 0.7
microbial colonization 0.7
muscle rigidity 0.7
urinary frequency 0.6
hypertonia 0.5
Neuropathic pain 0.3
spasm 0.2
HSA 0.2
skin damage 0.2
ophthalmoplegia 0.0
hypocapnia 0.0
hyperoxia -0.0
memory loss -0.1
analgesia -0.1
cachexia -0.1
sneezing -0.1
exhaustion -0.2
pain -0.2
hypercapnia -0.2
ataxia -0.2
collapse -0.2
diarrhea -0.3
more...
Drug
Parotin 8.8
Propagermanium 7.8
Ticlid 7.3
Sarpogrelate hydrochloride 7.1
Lisofylline 7.0
Tiotidine 6.8
Piriprost 6.7
Quisqualate 6.5
Myo-Inositol 6.4
Brij 96 6.3
Bitrex 6.2
Cevimeline 6.1
Arachidonic Acid 6.1
2'-Deoxyadenosine 6.1
Ticlopidine hydrochloride 6.1
Fenoldopam 6.0
Tenidap 6.0
Bifonazole 6.0
Neamine 5.7
K-252a 5.5
Avilamycin 5.5
MT6 5.4
Cilastatin 5.3
Olomoucine 5.3
PDGF B-chain 5.3
ETA 5.2
Darifenacin 5.2
Platelet Activating Factor 5.2
Pronase 5.1
Angiotensin II 5.1
4-Hydroxytamoxifen 5.0
RPH 5.0
Cinnarizine 4.9
Ibudilast 4.9
Fluphenazine 4.8
Forskolin 4.8
Butaprost 4.8
GHRP 4.8
Nafcillin 4.8
Sulprostone 4.8
more...
Enzyme
phospholipase C 10.8
phosphatidylinositol phospholipase A2 10.8
inositol-tetrakisphosphate 1-kinase 10.8
EC 3.1.3.57 9.8
PI-PLC 8.9
phospholipase D 8.6
GPI-specific phospholipase C 8.5
UDP-glucose:dolichol phosphate glucosyltransferase 8.4
GPI-PLD 8.3
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 8.2
Ins(1,4,5)P3 3-kinase 8.0
diacylglycerol kinase 8.0
phosphatidylinositol phospholipase C 8.0
PIP kinase 8.0
phosphoinositide 5-phosphatase 7.9
phosphatidylinositol 4-kinase 7.5
phospholipase A1 7.3
ceramide cholinephosphotransferase 7.3
phospholipase A2 7.2
aureolysin 7.2
glycerophosphocholine cholinephosphodiesterase 7.1
sphingomyelin synthase 7.0
protein kinase C 7.0
inositol polyphosphate kinase 6.9
phosphatidylinositol synthase 6.8
retinol isomerase 6.8
aminopeptidase P 6.8
phosphatidylinositol 3-phosphate 5-kinase 6.8
phosphocholine cytidylyltransferase 6.6
leishmanolysin 6.5
choline kinase 6.5
CDP-diacylglycerol synthase 6.5
ethanolamine kinase 6.4
acylcarnitine hydrolase 6.4
monoacylglycerol lipase 6.3
arachidonoyl-CoA synthetase 6.3
galactolipase 6.3
PNAE 6.2
alkylglycerol monooxygenase 6.2
sphingosine kinase 6.2
more...
Compound
1-(chloromethyl)naphthalene 10.8
N,N'-dihydroxyurea 10.8
Substance B 9.8
Inositol 1,2-cyclic phosphate 9.8
C10H13NO2 9.8
1,1,1-trifluoro-2-butanone 9.8
2,5-pyrrolidinedione 9.4
1H-pyrrole-2,5-dione 9.3
2,4,6-trimethylbenzenesulfonamide 9.2
inositol 1,4-bisphosphate 8.8
1,2,4-trimethylcyclohexane 8.8
1,2,4-trimethylcyclohexane 8.8
Inositol phosphate 8.6
Inositol 1,3,4-trisphosphate 8.5
Pseudoisocyanine 8.4
Dicumyl peroxide 8.4
Lophotoxin 8.3
Ins(1,4,5)P3 8.3
Succinimide 8.2
Methyltryptamine 8.2
Norbormide 8.2
Norbormide 8.2
piperidine oxalate 8.2
Neomycin sulfate 8.1
Neomycin sulfate 7.9
isobutyl propionate 7.9
GF 109203X 7.8
Neomycin 7.8
Methyl pyruvate 7.8
Gallein 7.7
Phosphatidylinositol 7.7
2-aminoethyl diphenylborinate 7.7
2-aminoethyl diphenylborinate 7.7
myo-inositol 1-phosphate 7.6
3-methyl-9H-carbazole 7.6
Gallein 7.6
Propagermanium 7.6
G11 7.5
K-38 7.4
propanoyl chloride 7.4
more...