Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The hypercoagulable state in pregnancy is partly caused by the increased activity of
factor VII
in plasma. We demonstrate here that this activity is reduced to levels similar to those in plasma from non-pregnant women by highly purified
phospholipase C
from Bacillus cereus, i.e. the activity increase is due to a circulating complex of
factor VII
and a
phospholipase C
-sensitive compound. Phospholipase C had no effect on the levels of factor II and X in blood from pregnant women. This novel form of activated
factor VII
is not inhibited by an antiserum to the protein component of thromboplastin (apoprotein III). By gel filtration of plasma from pregnant women on Sephadex G-100 the
phospholipase C
-sensitive complex was partly separated from non-phospholipase sensitive
factor VII
also present in the same plasma.
...
PMID:The coagulation factor VII in pregnancy. 660 66
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