Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Eosinophil-derived neurotoxin
(
EDN
) is one of the four basic proteins stored in specific eosinophil granules. Here we demonstrate that
EDN
can also be detected at the surface of granulocytes. Reduction of
EDN
membrane expression after phosphatidylinositol-specific
phospholipase C
treatment suggests that a glycosylphosphatidylinositol (GPI) anchor is involved in the membrane association of
EDN
. The presence of a GPI anchor was confirmed by a lower expression of membrane
EDN
on granulocytes from patients with paroxysmal nocturnal hemoglobinuria which present cells lacking GPI anchor proteins. Furthermore, metabolic labeling with GPI anchor components supports biochemical evidence of GPI anchoring of
EDN
.
...
PMID:Evidence for glycosylphosphatidylinositol (GPI)-anchored eosinophil-derived neurotoxin (EDN) on human granulocytes. 1260 41
