Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In order to study the structure-activity relationships of phenothiazine derivatives inhibiting phosphatidylinositol-specific
phospholipase C
(PI-PLC), the synthesis of some phenothiazine amide, amine and ester derivatives was performed mainly by reacting 10H-phenothiazine-10-
propanoyl chloride
with some amines and alcohols; the resulting amides were reduced with borane to yield the corresponding amines. Starting from 2-chloro and 2-trifluoromethyl-10H-phenothiazine-10-
propanoyl chloride
two amides were synthesized. The inhibiting activity on PI-PLC from human platelets is reported.
...
PMID:Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C. 138 3
