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Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The two isoforms of
phospholipase C
(
PLC
)-gamma couple immune recognition receptors to important calcium- and protein kinase C-dependent cellular functions. It has been assumed that
PLC
-gamma1 and
PLC
-gamma2 have redundant functions and that the receptors can use whichever
PLC
-gamma isoform is preferentially expressed in a cell of a given hemopoietic lineage. In this study, we demonstrate that ITAM-containing immune recognition receptors can use either
PLC
-gamma1 or
PLC
-gamma2, whereas the novel
NK cell-activating receptor
NKG2D preferentially couples to
PLC
-gamma2. Experimental models evaluating signals from either endogenous receptors (FcR vs NKG2D-DAP10) or ectopically expressed chimeric receptors (with ITAM-containing cytoplasmic tails vs DAP10-containing cytoplasmic tails) demonstrate that
PLC
-gamma1 and
PLC
-gamma2 both regulate the functions of ITAM-containing receptors, whereas only
PLC
-gamma2 regulates the function of DAP10-coupled receptors. These data suggest that specific immune recognition receptors can differentially couple to the two isoforms of
PLC
-gamma. More broadly, these observations reveal a basis for selectively targeting the functions initiated by distinct immune recognition receptors.
...
PMID:The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 1597 51
