Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report results of a study carried out to investigate photodynamic effect of Touildine blue (
TBO
) on virulent factors secreted by Pseudomonas aeruginosa. Viability of MCF-7 cells incubated with culture supernatants of bacteria photosensitized with
TBO
(experimental) was found to be higher than that for MCF-7 cells incubated with culture supernatants of bacterial cells treated either with
TBO
in dark (control II) or not receiving any treatment (neither
TBO
nor light (control I)). Furthermore, whereas MCF-7 cells incubated with supernatants of bacteria, control I and II, showed significant morphological alterations, no such changes were observed in MCF-7 cells incubated with supernatant of experimental cells. The activities of
phospholipase C
and proteases, virulent factors of P. aeruginosa, were also found to decrease on photosensitization. These results suggest that the potency of virulent factors is reduced in cells surviving photodynamic treatment with
TBO
and this may have implication in treatment of infections caused by P. aeruginosa.
...
PMID:Virulence of Pseudomonas aeruginosa cells surviving photodynamic treatment with toluidine blue. 1588 9
