Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.3 (phospholipase C)
 18,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parotin subunit (PS) is a unique glycoprotein, isolated from bovine parotid glands, which possesses the ability to induce polyclonal antibody production and IL-1-like activity. The present studies investigated the existence of receptors for PS on B cell surfaces using PS-affinity chromatography. No PS-binding proteins (PSR) solubilized from human B cell surfaces with Triton X-100 were detected, whereas the PSR released from human B cell membranes with phosphatidylinositol-specific phospholipase C (PI-PLC) treatment were composed of 75- and 40-kDa proteins. PI-PLC treatment markedly reduced polyclonal antibody responses to PS but weakly inhibited the responses to PWM, xanthan gum, and LPS in human and mouse lymphocytes. Addition of PSR caused a dose-related reduction in polyclonal IgM and IgG antibody responses to PS. These results suggest that PSR can act as glycosylphosphatidylinositol-anchored receptors for PS.
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PMID:Parotin subunit as a potent polyclonal B cell activator binds to newly found glycosylphosphatidylinositol (GPI)-anchored proteins on human B cell surfaces. 813 Dec 11