Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
alpha-toxin
of Staphylococcus pyogenes produced a slowly developing contracture of isolated preparations of rabbit jejunum and of guinea-pig ileum which persisted after thorough washing and left the gut unresponsive to further doses of
alpha-toxin
or of acetylcholine. After incubation with antitoxin, the
alpha-toxin
no longer produced a contracture. Antitoxin only prevented the
alpha-toxin
response if added to the bath fluid before but not after the
alpha-toxin
. Certain drugs reduced the
alpha-toxin
contracture when added to the bath fluid before or after the
alpha-toxin
, but the contracture reappeared on washing.
Papaverine
abolished the contracture and pethidine was only slightly less active. Mepyramine, amyl nitrite, caffeine, aminophylline, adrenaline and ephedrine partly reduced the contracture. Hexamethonium, cocaine, tubocurarine and gallamine had no effect. The effect of atropine was only small. The gut-stimulant activity/haemolytic unit of two
alpha-toxin
samples differed greatly; this difference did not appear to be due to activity of impurities. The implications of these observations are discussed.
...
PMID:Some pharmacological properties of the alpha-toxin of staphylococcus pyogenes. 1365 80
