Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of three phosphoinositide-specific
phospholipase C
(
PLC
) isotypes in rat olfactory epithelium was investigated using monoclonal antibodies. In intact animals,
PLC
beta 1 was not expressed in the olfactory epithelium but was found in glands below the epithelium. However, following unilateral olfactory bulbectomy (
OBX
),
PLC
beta 1 was expressed in the dentrites of some olfactory receptor neurons, primarily in the endoturbinates on the unoperated side.
PLC
gamma 1 immunoreactivity was found in the apices of sustentacular cells and in glands below the epithelium.
PLC
delta 1 immunoreactivity was found in the glands and in the perinuclear region and dendrites of some receptor neurons. Since none of the
PLC
isotypes studied were expressed in the cilia of receptor neurons, the results suggest that another
PLC
isotype is likely to be involved in mediating olfactory transduction.
...
PMID:Identification of three phospholipase C isotypes expressed in rat olfactory epithelium. 775 99
