Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.3 (phospholipase C)
 18,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Male and female nude mice of the HRS strain were exposed to single UV-B-irradiation with biologically effective doses of 1.0 and 1.4 kJ/m2 at an intensity of 0.11 and 0.59 W/m2. The general resistance of animals was measured in terms of skin automicroflora and resistance to Staphylococcus aureus alpha-toxin injected intraperitoneally at LD50. The amount of microorganisms of the back and tail skin (shielded during exposure) did not differ from the control level 1 hour or 1, 3, 7, 14, and 21 days after irradiation. One day after exposure to UV-irradiation at a dose of 1.4 kJ/m2, toxin resistance declined. The lethality rate of mice was 33.6% and 17.9% at an intensity of UV-irradiation equal to 0.59 W/m2 and 0.11 W/m2, respectively. No effect was observed 3 days after UV-irradiation at a dose of 1.0 kJ/m2. It is concluded that single UV-irradiation with 7 MEDs can decrease body resistance, the decrease enhancing with intensity increase.
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PMID:[The effect of singly-administered super-erythematous doses of UV-radiation on the general body resistance of hairless mice]. 196 Sep 42

Hairless mice of strain HRS were exposed to vertical UV-B-irradiation (280-320 nm) at daily doses of 1 or 2 kJ/m2 (biologically effective doses 200 and 400 J/m2) five days a week for 13 and 6 weeks. As the length of exposure increased, the abundance of automicroflora of the dorsal skin first decreased, then exceeded the control value, was normalized, and remained at the normal level until the end of the experiment. The rates of effect appearance and disappearance, just as its amplitude, increased with the daily doses. No changes were found in resistance to staphylococcal alpha-toxin after its post-irradiation intraperitoneal injection.
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PMID:[The effect of long-term UV radiation exposure on the skin autonomous microflora and on body nonspecific resistance]. 899 33