Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TRPM7 (ChaK1, TRP-PLIK,
LTRPC7
) is a ubiquitous, calcium-permeant ion channel that is unique in being both an ion channel and a serine/threonine kinase. The kinase domain of TRPM7 directly associates with the C2 domain of
phospholipase C
(
PLC
). Here, we show that in native cardiac cells and heterologous expression systems, G alpha q-linked receptors or tyrosine kinase receptors that activate
PLC
potently inhibit channel activity. Numerous experimental approaches demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP(2)), the substrate of
PLC
, is a key regulator of TRPM7. We conclude that receptor-mediated activation of
PLC
results in the hydrolysis of localized PIP(2), leading to inactivation of the TRPM7 channel.
...
PMID:The TRPM7 channel is inactivated by PIP(2) hydrolysis. 1194 71
