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Target Concepts:
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Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is known that desensitization of GABA
A
receptor (GABA
A
R)-mediated currents is paradoxically correlated with the slowdown of their deactivation, i.e., resensitization. It has been shown that an upregulation of calcineurin enhances the desensitization of GABA
A
R-mediated currents but paradoxically prolongs the decay phase of inhibitory postsynaptic currents/potentials without appreciable diminution of their amplitudes. The paradoxical correlation between desensitization and resensitization of GABA
A
R-mediated currents can be more clearly seen in response to a prolonged application of GABA to allow more desensitization, instead of brief pulse used in previous studies. Indeed, hump-like GABA
A
R currents were produced after a strong desensitization at the offset of a prolonged puff application of GABA in pyramidal cells of the barrel cortex, in which calcineurin activity was enhanced by deleting
phospholipase C
-related catalytically inactive proteins to enhance the desensitization/resensitization of GABA
A
R-mediated currents. Hump-like GABA
A
R currents were also evoked at the offset of propofol or barbiturate applications in hippocampal or sensory neurons, but not GABA applications. Propofol and barbiturate are useful to treat benzodiazepine/
alcohol withdrawal syndrome
, suggesting that regulatory mechanisms of desensitization/resensitization of GABA
A
R-mediated currents are important in understanding benzodiazepine/
alcohol withdrawal syndrome
. In this review, we will discuss the molecular and regulatory mechanisms underlying the desensitization and resensitization of GABA
A
R-mediated currents and their functional significances.
...
PMID:Molecular and Regulatory Mechanisms of Desensitization and Resensitization of GABA
A
Receptors with a Special Reference to Propofol/Barbiturate. 3195 24
