Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thromboangitis obliterans
(
TAO
) is considered to be an inflammatory disease. Previous research has demonstrated that phosphatidylcholine-specific
phospholipase C
(PC-PLC) plays critical roles in various inflammatory responses. However, the connection between PC-PLC and
TAO
is undetermined. Therefore, we sought to investigate whether PC-PLC was implicated in
TAO
. In our study, there were two groups:
TAO
group and control group. The PC-PLC activity of serum of two groups (16
TAO
patients and 11 controls) was detected by PC-PLC activity assay. The level and distribution of PC-PLC in posterior tibial arteries in seven
TAO
patients and four controls were detected by immunofluorescence staining method. PC-PLC activity increased greatly in serum of
TAO
patients. Immunofluorescence analysis also revealed an upregulation of PC-PLC in the vascular endothelium of
TAO
patients. Our data suggest that PC-PLC activity and level increase obviously in
TAO
patients. Our study may provide new clues for seeking pathogenesis of
TAO
. Furthermore, it may bring new insights into clinical diagnosis and treatment of
TAO
.
...
PMID:Phosphatidylcholine-specific phospholipase C activity and level increase evidently in thromboangitis obliterans. 2023 48
