Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.3 (
phospholipase C
)
18,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Given the role of phosphoinositide-specific
phospholipase C
(
PLC
) isozymes in the control of cell growth and differentiation we were prompted to analyze the expression of some of these
PLC
in human
bronchoalveolar carcinoma
-derived alveolar epithelial A549 cells. The effects of several fluoro-edenite fibers were compared with those of tremolite, a member of the calcic amphibole group of asbestos that originates from Calabria (Italy), and crocidolite, that, due to its high toxicity, is one of the most studied asbestos amphiboles. Our data show an increased expression of both
PLC
beta1 and
PLC
gamma1 in A549 cells treated with asbestos-like fibers, hinting at a role of
PLC
signalling in those cancerous cells.
...
PMID:Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells. 1914 71
