Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
 18,767 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
phosphodiesterase 0.956
nucleotide pyrophosphatase 0.026
PDE4 0.018
PDE 0.017
cyclic nucleotide phosphodiesterase 0.013
AMP 0.010
exonuclease I 0.009
PDE5 0.009
adenylate cyclase 0.008
cyclic AMP phosphodiesterase 0.008
PDE2 0.006
cGMP phosphodiesterase 0.005
PDE4B 0.003
PDE4A 0.003
guanylate cyclase 0.003
Phosphodiesterase 0.003
cGMP-PDE 0.003
calmodulin 0.002
adenylyl cyclase 0.002
GMP 0.002
Cyclic nucleotide phosphodiesterase 0.002
PDE3B 0.002
cAMP-specific phosphodiesterase 0.001
endothelin receptor 0.001
PDE7 0.001
PDE1A 0.001
PKG 0.001
PDE2A 0.001
phosphomonoesterase 0.001
guanylyl cyclase 0.001
PDE1C 0.001
cAMP-dependent protein kinase 0.001
calmodulin-dependent phosphodiesterase 0.001
TDP1 0.001
soluble guanylyl cyclase 0.001
adenyl cyclase 0.001
PDE10A 0.001
NPP2 0.001
dunce 0.001
NPP1 0.001
PDE5A 0.001
Cyclic AMP phosphodiesterase 0.001
PDE7A 0.001
PDE1B 0.001
PDE8A 0.001
PDE4C 0.001
Autotaxin 0.001
alkaline phosphomonoesterase 0.001
5'-nucleotidase 0.001
PDE11A 0.001
PKA 0.001
rhodopsin 0.001
pyrophosphatase 0.001
PDE9A 0.000
ENPP1 0.000
tyrosyl-DNA phosphodiesterase 1 0.000
CGI 0.000
CaM-PDE 0.000
GTP 0.000
adenosine receptor 0.000
cGMP-phosphodiesterase activity 0.000
rd1 0.000
transducin alpha 0.000
MIX 0.000
PC-1 0.000
PDE8B 0.000
Dictyostelium 0.000
nitric oxide synthase 0.000
ATP 0.000
PDEB 0.000
NPP6 0.000
PDE7B 0.000
PDE3B protein 0.000
PDE7B protein 0.000
DHH 0.000
phosphodiesterase 5A 0.000
ADP 0.000
rhodopsin kinase 0.000
PDE7A1 0.000
GAF 0.000
more...
Disease
PDE 0.016
erectile dysfunction 0.008
pulmonary hypertension 0.001
Pulmonary arterial hypertension 0.001
SCAN1 0.001
cholera 0.000
chronic obstructive pulmonary disease 0.000
heart failure 0.000
premature ejaculation 0.000
pertussis 0.000
asthma 0.000
sexual dysfunction 0.000
right heart failure 0.000
hypertension 0.000
NAME 0.000
acrodysostosis 0.000
congestive heart failure 0.000
persistent pulmonary hypertension of the newborn 0.000
atopic dermatitis 0.000
Hyperdynamic septic shock 0.000
Primary apnoea 0.000
intermittent claudication 0.000
Portopulmonary hypertension 0.000
EMD 0.000
retinitis pigmentosa 0.000
organic sexual dysfunction 0.000
priapism 0.000
primary pulmonary hypertension 0.000
female sexual arousal disorder 0.000
LCA4 0.000
Mietens' syndrome 0.000
Drug-induced sexual dysfunction 0.000
Gastric mucosal lesion 0.000
Peyronie's disease 0.000
psoriasis 0.000
psoriatic arthritis 0.000
Nonarteritic anterior ischemic optic neuropathy (NAION) 0.000
ischemia 0.000
GACI 0.000
sympathomimetic 0.000
COPD 0.000
hypogonadism 0.000
Sexual dysfunction 0.000
diabetes 0.000
Toxic optic neuropathy 0.000
hypoactive sexual desire disorder 0.000
Raynaud's phenomenon 0.000
impotence 0.000
stroke 0.000
RP26 0.000
Neuroleptic-induced tardive dyskinesia 0.000
dyspepsia 0.000
learning defect 0.000
Female sexual dysfunction 0.000
PSS 0.000
Idiopathic pulmonary arterial hypertension 0.000
depression 0.000
heart disease 0.000
SDS 0.000
neuroblastoma 0.000
High altitude pulmonary edema 0.000
Radiation esophagitis 0.000
achromatopsia 0.000
CHEST 0.000
NPH 0.000
vascular disease 0.000
PAF 0.000
Chromium deficiency 0.000
cardiovascular disease 0.000
Decompensated heart failure 0.000
pulmonary edema 0.000
Acute heart failure 0.000
atherosclerosis 0.000
cancer 0.000
connective tissue disease 0.000
Free plasma hemoglobin 0.000
IHG 0.000
myocardial ischemia 0.000
Hepatopulmonary syndrome 0.000
nephrogenic diabetes insipidus 0.000
more...
Symptom
Lower urinary tract symptoms 0.000
Ureteric colic 0.000
flushing 0.000
Central cyanosis 0.000
nasal congestion 0.000
Muscle fibrosis 0.000
headache 0.000
starvation 0.000
nausea 0.000
vomiting 0.000
hyperoxia 0.000
dyspnea 0.000
diarrhea 0.000
Hangover 0.000
astasia 0.000
memory loss 0.000
spasm 0.000
bitter taste 0.000
pain 0.000
ataxia 0.000
Urinary symptoms 0.000
skin pain 0.000
anesthesia 0.000
hypothermia 0.000
Periodic breathing 0.000
functional recovery 0.000
dizziness 0.000
angina 0.000
twitching 0.000
Visual symptoms 0.000
nausea and vomiting 0.000
polyuria 0.000
fatigue 0.000
despair 0.000
seizures 0.000
Decreased activity 0.000
photopsia 0.000
retching 0.000
No adverse effect 0.000
nocturnal polyuria 0.000
acute pain 0.000
respiratory distress 0.000
Spastic 0.000
cough 0.000
pachyonychia 0.000
cyanosis 0.000
syncope 0.000
Noise-induced hearing loss 0.000
motor symptom 0.000
exertional dyspnea 0.000
tonic seizure 0.000
rundown 0.000
inanition 0.000
polydipsia 0.000
colic 0.000
hypercapnia 0.000
myalgia 0.000
incoordination 0.000
tremor 0.000
prostatism 0.000
elbow pain 0.000
autodigestion 0.000
Excitability 0.000
chronic cough 0.000
clonus 0.000
analgesia 0.000
hyperacusis 0.000
hangover 0.000
thinning 0.000
loss of taste 0.000
photophobia 0.000
Involuntary Movement 0.000
constipation 0.000
abdominal discomfort 0.000
cachexia 0.000
catatonia 0.000
productive cough 0.000
erythema 0.000
POA 0.000
swollen joints 0.000
more...
Drug
Rolipram 0.011
Cilostazol 0.004
Vardenafil 0.003
Viagra 0.003
Roflumilast 0.003
Roflumilast 0.003
Enoximone 0.002
CIA 0.002
Viagra 0.002
Forskolin 0.001
Cilomilast 0.001
Amrinone 0.001
Levitra 0.001
Theophylline 0.001
Levitra 0.001
Pimobendan 0.001
Ibudilast 0.001
Papaverine 0.001
Avanafil 0.000
Piclamilast 0.000
Piclamilast 0.000
Levosimendan 0.000
caffeine 0.000
Vinpocetine 0.000
Quazinone 0.000
Indolidan 0.000
Piroximone 0.000
Vesnarinone 0.000
Trapidil 0.000
Propentofylline 0.000
Sodium nitroprusside 0.000
Bosentan 0.000
Bosentan 0.000
Toborinone 0.000
Anagrelide 0.000
2-Fluoroadenosine 0.000
Bemoradan 0.000
R-Rolipram 0.000
Trifluoperazine 0.000
ICI 0.000
Enprofylline 0.000
Inocor 0.000
Quazodine 0.000
Carbazeran 0.000
Ethyl icosapentate 0.000
Warfarin potassium 0.000
Primacor 0.000
Treprostinil 0.000
Monoammonium glycyrrhizinate 0.000
Talniflumate 0.000
Etacrynic acid 0.000
Beraprost 0.000
Iloprost 0.000
S-Ethylisothiourea 0.000
Anginin 0.000
Primacor 0.000
Histamine 0.000
Salbutamol 0.000
Glucagon 0.000
Lysophosphatidylglycerol 0.000
Nesiritide 0.000
Doxofylline 0.000
nitroglycerin 0.000
Darodipine 0.000
Cardiovasc 0.000
Trental 0.000
Agrylin 0.000
Leminoprazole 0.000
CaCl2 0.000
CaCl2 0.000
Secretin 0.000
CaCl2 0.000
Ephedrae Herba 0.000
Adenosine deaminase 0.000
Gris-PEG 0.000
Omnic 0.000
Indomethacin 0.000
Stenorol 0.000
Pinellia tuber 0.000
2'-Deoxyadenosine 0.000
more...
Enzyme
phosphodiesterase 1.000
PDE 0.033
exonuclease I 0.011
cGMP phosphodiesterase 0.009
adenylate cyclase 0.009
nucleotide pyrophosphatase 0.005
guanylate cyclase 0.004
protein kinase 0.002
PKG 0.001
3'-exonuclease 0.001
5'-nucleotidase 0.001
lysophospholipase D 0.001
AMPK 0.001
3'-phosphatase 0.000
glycerophosphocholine cholinephosphodiesterase 0.000
venom phosphodiesterase 0.000
glycerophosphocholine phosphodiesterase 0.000
AcpH 0.000
protein kinase C 0.000
rhodopsin kinase 0.000
alkaline phosphatase 0.000
exonuclease VII 0.000
NO synthase 0.000
adenosine deaminase 0.000
adenosine deaminase 0.000
acid phosphatase 0.000
polynucleotide kinase 0.000
yeast ribonuclease 0.000
nucleotidase 0.000
phospholipase C 0.000
myosin light chain kinase 0.000
DNA polymerase 0.000
calcineurin 0.000
ATPase 0.000
EC 3.6.1.17 0.000
mannosylphosphodolichol phosphodiesterase 0.000
EC 3.6.1.29 0.000
CMP-sialic acid hydrolase 0.000
endonuclease 0.000
RNA ligase 0.000
exoribonuclease H 0.000
EC 2.7.7.53 0.000
CNPase 0.000
DNA ligase 0.000
DNA ligase 0.000
phospholipase A2 0.000
DNA 3'-phosphatase 0.000
cytidylate cyclase 0.000
phosphoinositide 5-phosphatase 0.000
cytochrome c methyltransferase 0.000
dTMPase 0.000
aminopeptidase S 0.000
exonuclease V 0.000
thrombin 0.000
phosphorylase 0.000
Escherichia coli exonuclease III 0.000
EC 4.1.1.46 0.000
oligoribonuclease 0.000
CPT 0.000
DNase 0.000
CPT 0.000
phospholipase D 0.000
NOS 0.000
ribonuclease F 0.000
phosphoglycerol transferase 0.000
glycerophosphodiester phosphodiesterase 0.000
RNase 0.000
NAD glycohydrolase 0.000
ADPase 0.000
mitogen-activated protein kinase 0.000
RNase 0.000
topoisomerase 0.000
ATP diphosphohydrolase 0.000
DNase II 0.000
ADP-sugar pyrophosphatase 0.000
topoisomerase 0.000
apyrase 0.000
hormone-sensitive lipase 0.000
UDP-sugar hydrolase 0.000
FAD-AMP lyase 0.000
more...
Compound
cAMP 0.021
cGMP 0.021
Sildenafil 0.011
AMP 0.010
GMP 0.005
Milrinone 0.003
Theophylline 0.001
Forskolin 0.001
calcium 0.001
nitric oxide 0.001
2-imidazolidinone 0.001
Pentoxifylline 0.001
prostaglandin E1 0.001
prostacyclin 0.001
adenylate 0.001
Papaverine 0.001
8-Br-cGMP 0.001
SQ 20009 0.000
4-methoxybenzyl 0.000
caffeine 0.000
GTP 0.000
ATP 0.000
Dibutyryl cyclic AMP 0.000
Dibutyryl cyclic AMP 0.000
ADP 0.000
sodium 0.000
Isoproterenol 0.000
phosphate 0.000
ADP 0.000
nonyl 0.000
ADP 0.000
DEAE 0.000
Adenosine 0.000
Aminophylline 0.000
Olprinone hydrochloride 0.000
arginine 0.000
PGE2 0.000
4-methoxybenzamide 0.000
Sulmazole 0.000
Mg2+ 0.000
noradrenaline 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
8-Bromoadenosine 0.000
3'-AMP 0.000
Cytosine arabinoside monophosphate 0.000
C19H16O3 0.000
1-ethyl-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione 0.000
C19H16O3 0.000
Leniquinsin 0.000
Linderane 0.000
C19H16O3 0.000
N-(3,4-dimethoxyphenyl)acetamide 0.000
8-Bromoinosine 0.000
N-neopentylacetamide 0.000
C19H16O3 0.000
C19H16O3 0.000
C19H16O3 0.000
C22H30N6 0.000
DNA 0.000
Dipyridamole 0.000
Dipyridamole 0.000
Dipyridamole 0.000
Dipyridamole 0.000
GDP 0.000
NPP 0.000
8-methylquinoline 0.000
Atherosperminine 0.000
C16H16O3 0.000
Milrinone lactate 0.000
Dehydroheliotridine 0.000
AMP 2'-phosphate 0.000
2-Fluoroadenosine 0.000
trimethyllysine 0.000
Carbachol 0.000
cyclopentyl 0.000
more...