Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
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Human Gene/Protein
HSPDE4D 10.7
PDE4C-delta54 10.7
TRBV6-2 10.7
membrane interacting protein of RGS16 10.7
PDE8A protein 10.7
phospholipase A2, group VII 10.7
nebulin-related anchoring protein isoform C 10.7
PDE4C-426 10.7
TRBV6-3 10.7
PDE7B protein 10.7
DPDE2 10.7
inositoltrisphosphohydrolase 10.7
PDE4C-delta109 10.7
PDE4C-791 10.7
PRO1598 10.7
triphosphoinositide phosphodiesterase 10.7
sema domain, transmembrane domain 10.7
transmembrane channel-like 7 10.7
phosphodiesterase 10.7
guanylate cyclase 1, soluble, beta 3 10.7
ectonucleotide pyrophosphatase/phosphodiesterase 6 10.7
CGS-PDE 10.7
ADP-ribosylation factor interacting protein 1 10.7
PDE1A5 10.7
alanyl-tRNA synthetase domain containing 1 10.7
Hcam3 10.7
spectrin, beta, non-erythrocytic 1 10.7
PDE4B5 10.7
exonuclease I 10.4
CaM-PDE 10.4
nucleotide pyrophosphatase 10.2
PDE3B protein 10.1
PDE10A1 10.0
cGMP-PDE 10.0
PDE2 10.0
PDE1C 9.9
Cyclic nucleotide phosphodiesterase 9.9
NPP2 9.9
PDE4A 9.9
PDE8A 9.9
NPP6 9.9
PDE1A 9.8
PDE7A 9.8
PDE4 9.8
PDE1B 9.8
PDE7 9.7
melanoma-derived protein 9.7
protein kinase C, theta 9.7
HCAM1 9.7
DPDE3 9.7
G-protein-coupled receptor kinase 1 9.7
PDE1B1 9.7
transforming growth factor, beta 2 9.7
GDPD1 9.7
G-protein coupled receptor 35 9.7
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 9.7
DPDE1 9.7
CEBPB protein 9.7
FHL-3 9.7
5-hydroxytryptamine (serotonin) receptor 2B 9.7
protein kinase C alpha type 9.7
rho GTPase activating protein 9.7
PDE2A 9.7
Cyclic AMP phosphodiesterase 9.6
cGMP-phosphodiesterase activity 9.6
PDE6G 9.6
3',5'-cyclic-nucleotide phosphodiesterase 9.6
TDP1 9.6
PDE4C 9.6
calmodulin-dependent phosphodiesterase 9.6
PDE4B 9.6
PDE11A1 9.6
cyclic nucleotide phosphodiesterase 9.6
PDE5 9.5
NPP5 9.5
PDE3B 9.5
PDE11A 9.4
PDE7A1 9.4
GDPD5 9.4
TOP1 protein 9.4
more...
Disease
Hyperdynamic septic shock 10.7
Primary apnoea 10.7
SCAN1 9.9
organic sexual dysfunction 9.7
PDE 9.2
Mietens' syndrome 8.7
Drug-induced sexual dysfunction 8.7
Gastric mucosal lesion 8.7
LCA4 8.7
Nonarteritic anterior ischemic optic neuropathy (NAION) 8.0
erectile dysfunction 7.9
acrodysostosis 7.9
GACI 7.9
Toxic optic neuropathy 7.9
RP26 7.6
Neuroleptic-induced tardive dyskinesia 7.6
Portopulmonary hypertension 7.5
female sexual arousal disorder 7.4
Pulmonary arterial hypertension 7.3
Radiation esophagitis 7.1
learning defect 7.1
Chromium deficiency 6.9
High altitude pulmonary edema 6.9
Decompensated heart failure 6.8
Free plasma hemoglobin 6.7
IHG 6.7
premature ejaculation 6.7
PPD2 6.6
Proximal renal tubular acidosis 6.6
Ejaculatory dysfunction 6.6
Idiopathic pulmonary arterial hypertension 6.5
Retinal dystrophy 6.5
Persistent pulmonary hypertension 6.3
Female sexual dysfunction 6.3
CHEST 6.3
Axonal Neuropathy 6.3
persistent pulmonary hypertension of the newborn 6.3
Performance anxiety 6.2
Pleuropneumonia 6.2
sexual dysfunction and infertility 6.2
Congenital heart block 6.2
hypoactive sexual desire disorder 6.2
Substance dependence 5.9
RP12 5.9
Congenital chylothorax 5.9
Cardiac autonomic neuropathy 5.8
Erythrodermic psoriasis 5.8
Secondary pulmonary hypertension 5.8
Acrodermatitis continua of Hallopeau 5.7
Hepatopulmonary syndrome 5.7
Acute heart failure 5.6
Sexual dysfunction 5.5
Peyronie's disease 5.5
EMD 5.5
NINA 5.5
Retinal vasculitis 5.4
achromatopsia 5.4
pulmonary hypertension 5.4
hydroxyapatite deposition 5.4
Age-related cognitive decline 5.4
mammillitis 5.4
Acute angle-closure glaucoma 5.4
PAPA 5.4
priapism 5.4
necrospermia 5.3
right heart failure 5.3
homocystinemia 5.3
Flashing 5.3
intermittent claudication 5.3
hemiparkinsonism 5.3
sexual dysfunction 5.3
primary pulmonary hypertension 5.2
Pulmonary veno-occlusive disease 5.2
Anterior ischemic optic neuropathy 5.2
cerebral neoplasm 5.1
dactylitis 5.1
Androgen deficiency 5.1
lymphoblastoma 5.0
Erythema nodosum leprosum 5.0
Diabetic autonomic neuropathy 5.0
more...
Symptom
Ureteric colic 8.7
Central cyanosis 7.7
Muscle fibrosis 7.4
Lower urinary tract symptoms 7.1
Hangover 5.1
nasal congestion 4.9
astasia 4.8
Urinary symptoms 4.5
skin pain 4.5
Periodic breathing 4.3
Visual symptoms 3.9
flushing 3.8
photopsia 3.7
nocturnal polyuria 3.5
No adverse effect 3.4
bitter taste 3.3
Decreased activity 3.3
Spastic 3.3
pachyonychia 3.2
retching 3.2
Noise-induced hearing loss 3.1
tonic seizure 3.0
inanition 2.9
motor symptom 2.8
hyperoxia 2.8
rundown 2.8
twitching 2.7
memory loss 2.7
despair 2.7
prostatism 2.6
elbow pain 2.5
autodigestion 2.4
Excitability 2.4
nausea 2.3
starvation 2.3
polyuria 2.3
hyperacusis 2.2
hangover 2.2
clonus 2.2
spasm 2.2
loss of taste 2.2
Involuntary Movement 2.1
vomiting 2.0
headache 2.0
acute pain 1.9
polydipsia 1.9
incoordination 1.9
cyanosis 1.9
exertional dyspnea 1.8
chronic cough 1.7
dizziness 1.7
photophobia 1.7
colic 1.7
POA 1.7
swollen joints 1.7
dyspnea 1.7
ataxia 1.6
Anoxia 1.6
catatonia 1.6
productive cough 1.6
nausea and vomiting 1.6
abdominal discomfort 1.6
functional recovery 1.5
presyncope 1.5
hypothermia 1.4
asynergy 1.4
leg edema 1.3
Neuropathic pain 1.3
syncope 1.3
myalgia 1.2
angina 1.2
hypercapnia 1.1
renal colic 1.1
dysuria 1.1
pallor 1.0
diarrhea 1.0
tachypnea 1.0
neurological disability 0.9
respiratory distress 0.9
cachexia 0.8
more...
Drug
Quazinone 10.7
Piclamilast 10.4
Piclamilast 10.4
Indolidan 10.2
Rolipram 10.2
Cilomilast 10.1
Avanafil 10.1
Roflumilast 10.0
Roflumilast 10.0
Vardenafil 9.8
Levitra 9.8
Enoximone 9.8
R-Rolipram 9.7
2-Fluoroadenosine 9.7
Ibudilast 9.6
Piroximone 9.5
Levitra 9.5
Cilostazol 9.4
Pimobendan 9.4
Carbazeran 9.1
Inocor 9.1
Quazodine 9.1
Warfarin potassium 9.1
Ethyl icosapentate 9.1
Primacor 9.1
Bemoradan 8.9
Viagra 8.9
Toborinone 8.9
Amrinone 8.8
Viagra 8.7
Talniflumate 8.7
Monoammonium glycyrrhizinate 8.7
Etacrynic acid 8.7
S-Ethylisothiourea 8.4
Anginin 8.4
Primacor 8.4
CIA 8.4
Vesnarinone 8.4
Vinpocetine 8.3
Lysophosphatidylglycerol 8.1
Levosimendan 8.0
Papaverine 7.9
Darodipine 7.9
Leminoprazole 7.7
Agrylin 7.7
Propentofylline 7.7
Trapidil 7.6
Gris-PEG 7.6
Anagrelide 7.4
Stenorol 7.4
Pinellia tuber 7.4
Doxofylline 7.4
Enprofylline 7.3
Beraprost 7.3
Forskolin 7.3
Theophylline 7.3
Omnic 7.2
Treprostinil 7.1
2'-Deoxyadenosine 7.0
Ephedrae Herba 7.0
Epinastine 6.9
Edetate disodium 6.8
Piriprost 6.6
Tamsulosin hydrochloride 6.6
Flosequinan 6.6
Gardenia fruit 6.6
Nesiritide 6.5
Bosentan 6.5
Bosentan 6.5
Stelazine 6.4
Nipent 6.3
Cicletanine 6.3
Scutellaria root 6.3
Flolan 6.3
PT-141 6.3
Amlexanox 6.3
Trental 6.3
Bitrex 6.2
Trifluoperazine 6.2
Flolan 6.1
more...
Enzyme
phosphodiesterase 10.7
mannosylphosphodolichol phosphodiesterase 10.7
exonuclease I 10.6
yeast ribonuclease 10.1
AcpH 10.1
glycerophosphocholine cholinephosphodiesterase 10.0
nucleotide pyrophosphatase 9.8
exoribonuclease H 9.7
cGMP phosphodiesterase 9.5
PDE 9.4
CMP-sialic acid hydrolase 9.4
glycerophosphocholine phosphodiesterase 9.3
cytochrome c methyltransferase 9.1
aminopeptidase S 9.1
dTMPase 9.1
EC 2.7.7.53 8.9
EC 4.1.1.46 8.7
EC 3.6.1.29 8.6
cytidylate cyclase 8.6
lysophospholipase D 8.5
ribonuclease F 8.4
EC 3.6.1.17 8.3
exonuclease VII 8.3
3'-exonuclease 8.2
3'-phosphatase 8.2
ADP-sugar pyrophosphatase 8.1
pterin deaminase 7.9
phosphoglycerol transferase 7.9
FAD-AMP lyase 7.9
DNA 3'-phosphatase 7.9
UDP-glucose:glycoprotein glucose-1-phosphotransferase 7.9
lysoplasmalogenase 7.6
UDP-sugar hydrolase 7.6
7alpha-dehydroxylase 7.6
oligoribonuclease 7.5
ADP-ribosylarginine hydrolase 7.5
phosphoinositide 5-phosphatase 7.4
deoxynucleoside monophosphate kinase 7.4
venom phosphodiesterase 7.3
adenylate cyclase 7.3
PKG 7.3
guanylate cyclase 7.3
geranylgeranyltransferase II 7.3
rhodopsin kinase 7.2
galactosyltransferase II 7.1
exonuclease V 7.1
phosphoamidase 7.0
RVV-V 7.0
3'(2'),5'-bisphosphate nucleotidase 7.0
exodeoxyribonuclease 7.0
N-acetylglucosaminylphosphotransferase 7.0
GMP synthase 6.9
EC 2.7.7.25 6.9
2',3'-cyclic nucleotide phosphohydrolase 6.9
peptidase E 6.9
glycerophosphodiester phosphodiesterase 6.9
alpha-N-acetylglucosaminyl phosphodiesterase 6.9
PHOSPHO1 6.9
Escherichia coli exonuclease III 6.8
NADH pyrophosphatase 6.8
Ap4A hydrolase 6.7
FAD pyrophosphatase 6.7
5'-nucleotidase 6.7
phosphoglucosamine mutase 6.6
chondro-4-sulfatase 6.6
phosphonoacetate hydrolase 6.5
K+-transporting ATPase 6.5
ATP diphosphohydrolase 6.5
polynucleotide kinase 6.5
YgjG 6.4
NAD+ kinase 6.3
GMP synthetase 6.3
N-acetylglucosamine-6-phosphate deacetylase 6.3
pipecolate oxidase 6.3
ATP(CTP):tRNA nucleotidyltransferase 6.2
holo-ACP synthase 6.1
CNPase 6.1
nucleotidase 6.1
RNA ligase 6.0
poly(ADP-ribose) glycohydrolase 6.0
more...
Compound
Olprinone hydrochloride 10.7
C19H16O3 10.7
C19H16O3 10.7
C19H16O3 10.7
C22H30N6 10.7
8-Bromoinosine 10.7
N-neopentylacetamide 10.7
Leniquinsin 10.7
C19H16O3 10.7
N-(3,4-dimethoxyphenyl)acetamide 10.7
Cytosine arabinoside monophosphate 10.7
Linderane 10.7
C19H16O3 10.7
1-ethyl-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione 10.7
C19H16O3 10.7
SQ 20009 10.0
2-Fluoroadenosine 9.7
Dehydroheliotridine 9.7
Atherosperminine 9.7
C16H16O3 9.7
AMP 2'-phosphate 9.7
Milrinone lactate 9.7
Sildenafil 9.5
Milrinone 9.4
Reticulol 9.1
2-Phenylaminoadenosine 9.1
C13H10O3 9.1
Sch 15280 9.1
Phthalazinol 9.1
Tiaramide hydrochloride 9.1
C20H24N2O2 9.1
Hydrocortisone phosphate 9.1
C14H20O3 9.1
2-imidazolidinone 8.9
Sulmazole 8.9
Chlorpromazine sulphoxide 8.7
C6H13NO3 8.7
Pentoxyl 8.7
C19H16O2 8.7
C11H9NO2 8.7
Kokusaginine 8.7
Etacrynic acid 8.7
Baxacor 8.7
8-iso-PGE1 8.6
4-methoxybenzamide 8.5
Adchnon 8.4
cyclohexanecarbaldehyde 8.4
Sciadopitysin 8.4
Stubomycin 8.4
RI-64 8.4
8-Bromoadenosine 8.2
8-Bromoadenosine 8.2
8-Bromoadenosine 8.2
8-Bromoadenosine 8.2
8-Bromoadenosine 8.2
8-Bromoadenosine 8.2
Aldophosphamide 8.1
4-methoxybenzohydrazide 8.1
Allocryptopine 8.1
8-Bromoadenosine 8.1
C19H22O3 8.1
Allocryptopine 8.1
Secobarbitone 8.1
Cymarin 8.1
Papaverine 7.9
C7H9N3O3 7.9
2-acetylbenzoic acid 7.9
Sarcolysine 7.9
cGMP 7.8
8-methylquinoline 7.8
Pentoxifylline 7.8
4-methoxybenzyl 7.7
SC-13504 7.7
Capillarisin 7.7
cTMP 7.7
8-Br-cGMP 7.7
8-Bromo-cyclic AMP 7.6
Chlorphenesin 7.6
Glaucine 7.6
Diadenosine tetraphosphate 7.5
more...