Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.1.4.1 (phosphodiesterase)
18,767 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein phosphodiesterase 17939 AMP 2695 adenylate cyclase 1652 Sep 1300 Mol 1073 calmodulin 1041 PDE 865 ATP 730 nucleotide pyrophosphatase 684 PDE4 646 insulin 615 adenylyl cyclase 581 cyclic nucleotide phosphodiesterase 567 guanylate cyclase 565 GTP 403 GMP 398 cyclic AMP phosphodiesterase 382 PDE5 374 nitric oxide synthase 354 ADP 340 cAMP-dependent protein kinase 336 cytokine 291 PKA 280 endothelin receptor 268 rhodopsin 267 cGMP phosphodiesterase 257 ATPase 255 alkaline phosphatase 254 Phosphodiesterase 250 tumor necrosis factor 249 glucagon 240 collagen 237 phosphatase 235 PKG 231 lipopolysaccharide 219 exonuclease I 211 guanylyl cyclase 211 membrane-bound 204 5'-nucleotidase 189 polypeptide 188 PDE2 182 soluble guanylyl cyclase 178 Dictyostelium 170 adenosine receptor 160 Gen 159 TNF 154 endonuclease 149 thrombin 149 vasopressin 145 calcium channel 144 cyclooxygenase 142 PDE4B 132 SDS 124 pyrophosphatase 124 adenyl cyclase 122 Pseudomonas 112 olfactory 110 GDP 109 NMR 109 TNF-alpha 108 adenosine deaminase 106 PDE4A 104 natriuretic peptide 98 dimeric 97 DNA polymerase 97 renin 94 CGI 94 microsomal 94 myelin basic protein 93 Autotaxin 91 angiotensin II 90 atrial natriuretic peptide 90 beta-endorphin 90 endoplasmic reticulum 89 IL-6 88 axonal 88 inducible nitric oxide synthase 88 spermatozoa 86 FSH 86 tyrosine kinase 86 more...

Disease erectile dysfunction 1006 PDE 865 hypertension 596 heart failure 509 cancer 498 pulmonary hypertension 473 asthma 438 tumor 365 diabetes 358 chronic obstructive pulmonary disease 339 cholera 290 pertussis 234 depression 233 stroke 233 ischemia 232 congestive heart failure 190 NAME 150 atherosclerosis 133 atopic dermatitis 132 Pulmonary arterial hypertension 128 cardiovascular disease 127 Alzheimer's disease 127 obesity 125 SDS 124 psoriasis 113 myocardial infarction 109 heart disease 102 sexual dysfunction 95 neuroblastoma 91 right heart failure 87 myocardial ischemia 82 schizophrenia 75 type 2 diabetes 75 glioma 73 multiple sclerosis 72 coronary artery disease 72 cold 72 retinitis pigmentosa 71 HIV 70 melanoma 70 prostate cancer 70 cognitive impairment 69 vascular disease 66 hepatocellular carcinoma 65 sepsis 63 sepsis 60 PSS 59 carcinoma 58 COPD 55 intermittent claudication 54 plaque 53 Parkinson's disease 53 breast cancer 52 psoriatic arthritis 51 pulmonary edema 49 Mycobacterium 48 uterus 48 lymphoma 48 hypogonadism 48 cerebral ischemia 47 cardiomyopathy 46 cystic fibrosis 46 premature ejaculation 45 tuberculosis 44 leukemia 44 lung disease 44 neuropathy 43 tumor growth 43 pruritus 43 dyspepsia 41 cirrhosis 40 metabolic syndrome 40 SEM 40 EMD 39 arthritis 39 encephalomyelitis 39 dementia 38 sympathomimetic 38 ventricular hypertrophy 37 primary pulmonary hypertension 37 more...

Symptom headache 130 pain 121 vomiting 76 starvation 74 anesthesia 72 nausea 70 diarrhea 68 dyspnea 52 flushing 51 seizures 48 fatigue 39 ataxia 29 angina 28 hypothermia 27 functional recovery 23 hyperoxia 22 cough 22 respiratory distress 21 nasal congestion 20 spasm 20 dizziness 19 nausea and vomiting 17 analgesia 17 Lower urinary tract symptoms 15 tremor 15 memory loss 14 collapse 13 syncope 13 thinning 10 hypercapnia 10 chest pain 9 myalgia 9 weakness 9 polyuria 9 erythema 9 constipation 9 acute pain 9 abdominal pain 8 agitation 8 bitter taste 8 twitching 8 cyanosis 8 overweight 8 discomfort 7 exertional dyspnea 7 exhaustion 7 discomfort 7 insomnia 7 back pain 7 cachexia 6 colic 6 despair 6 polydipsia 5 anorexia 5 incoordination 4 pelvic pain 4 chronic cough 4 vertigo 4 photophobia 3 dysuria 3 ophthalmoplegia 3 pallor 3 arthralgia 3 tachypnea 3 abdominal discomfort 3 HSA 3 retching 3 Decreased activity 3 hemoptysis 2 catatonia 2 blurred vision 2 rundown 2 splenomegaly 2 chorea 2 acute stress 2 No adverse effect 2 shortness of breath 2 bradykinesia 2 tinnitus 2 productive cough 2 more...

Drug caffeine 375 Rolipram 301 Cardiovasc 296 Forskolin 240 Theophylline 182 Cilostazol 168 Viagra 166 CIA 156 Dermatol 152 Viagra 118 Vardenafil 94 Roflumilast 78 Roflumilast 78 Enoximone 68 Papaverine 68 ICI 68 Amrinone 63 nitroglycerin 62 Histamine 55 lysine 54 Nephron 53 CaCl2 49 CaCl2 49 CaCl2 49 Gel 48 Levosimendan 46 Indomethacin 46 Glucagon 43 MAP 41 IFN-gamma 41 PTH 38 NADH 37 IL-2 35 Sodium nitroprusside 35 Levitra 31 Asthma 31 Levitra 31 Pimobendan 29 ROS 29 Cilomilast 28 Vinpocetine 27 Ibudilast 26 Salbutamol 23 Bosentan 22 Bosentan 22 Nitric Oxide 21 Atropine 20 CSF 20 CTX 19 Trifluoperazine 19 Asn 18 FAD 18 DNase I 17 Methylene blue 17 Ouabain 17 Iloprost 17 Ethanol 16 Fraction 16 Secretin 16 -deoxyadenosine 15 Vesnarinone 15 Adenosine deaminase 15 Phentolamine 14 Ringer's solution 14 ascorbate 14 CDP 14 Bayer 13 Angiotensin II 13 Trapidil 13 EE2 12 Avanafil 12 Apomorphine 12 Clonidine 11 lactose 11 Heme 10 Propentofylline 10 ABC 10 Piclamilast 9 Anagrelide 9 Piclamilast 9 more...

Enzyme phosphodiesterase 18767 adenylate cyclase 1785 protein kinase 1759 PDE 1513 guanylate cyclase 774 cGMP phosphodiesterase 409 protein kinase C 384 alkaline phosphatase 359 AMPK 348 ATPase 302 PKG 231 mitogen-activated protein kinase 223 exonuclease I 211 NO synthase 203 5'-nucleotidase 196 nucleotide pyrophosphatase 193 phospholipase C 178 acid phosphatase 163 DNA polymerase 159 calcineurin 155 thrombin 150 endonuclease 149 trypsin 132 phospholipase A2 114 adenosine deaminase 109 adenosine deaminase 106 RNase 96 renin 94 peroxidase 94 RNase 92 superoxide dismutase 87 ERK 85 acetylcholinesterase 73 3'-exonuclease 71 topoisomerase 71 DNase 68 topoisomerase 66 myosin light chain kinase 65 NOS 64 luciferase 63 phosphorylase 61 caspase-3 58 lactate dehydrogenase 55 collagenase 54 ACE 53 DNA ligase 50 DNA ligase 50 tyrosine hydroxylase 50 focal adhesion kinase 48 catalase 48 lysophospholipase D 47 ribonuclease 46 phospholipase D 46 ribonuclease 46 reverse transcriptase 46 beta-galactosidase 46 CPT 45 CPT 44 CPT 44 venom phosphodiesterase 43 nucleotidase 42 lipase 40 MEK 38 PARP 38 CaMKII 37 NADPH oxidase 37 hyaluronidase 36 NADPH oxidase 35 polynucleotide kinase 35 rhodopsin kinase 33 elastase 33 hyaluronidase 33 phosphatidylinositol 3-kinase 33 ornithine decarboxylase 32 ACS 32 beta-glucuronidase 31 hormone-sensitive lipase 31 lipoxygenase 30 3'-phosphatase 30 monoamine oxidase 29 more...

Compound cAMP 4820 AMP 2862 cGMP 2848 calcium 2537 Dec 1312 nitric oxide 1177 DNA 1051 GMP 970 sodium 949 phosphate 752 ATP 731 Clin 672 oxygen 576 glucose 490 arginine 462 Sildenafil 457 GTP 403 prostacyclin 403 ADP 397 water 390 caffeine 375 ADP 348 ADP 340 acetate 307 prostaglandin E1 294 Cardiol 278 potassium 273 Theophylline 272 adenylate 264 Forskolin 240 noradrenaline 230 Mg2+ 225 DEAE 212 sulfate 199 tyrosine 187 PGE2 167 TNF 154 glutamate 154 glycerol 153 Isoproterenol 147 hydrogen 143 salt 140 SDS 139 Adenosine 138 manganese 138 Phe 136 serine 128 zinc 128 EDTA 127 EDTA 126 Milrinone 123 leucine 118 His 114 GDP 113 5-HT 112 alanine 108 Insulin 107 ethanol 105 Pentoxifylline 103 nitrate 101 ammonium 98 Triton X-100 98 NAD 97 bromide 96 nitrogen 95 cysteine 92 galactose 91 methionine 85 lysine 85 threonine 84 PGE 82 urea 80 8-Br-cGMP 79 pyrimidine 71 pyrimidine 71 pyridine 70 phosphorus 69 iron 68 ICI 68 Papaverine 68 more...

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