Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.1 (
phosphodiesterase
)
18,767
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
phosphodiesterase
0.956
nucleotide pyrophosphatase
0.026
PDE4
0.018
PDE
0.017
cyclic nucleotide phosphodiesterase
0.013
AMP
0.010
exonuclease I
0.009
PDE5
0.009
adenylate cyclase
0.008
cyclic AMP phosphodiesterase
0.008
PDE2
0.006
cGMP phosphodiesterase
0.005
PDE4B
0.003
PDE4A
0.003
guanylate cyclase
0.003
Phosphodiesterase
0.003
cGMP-PDE
0.003
calmodulin
0.002
adenylyl cyclase
0.002
GMP
0.002
Cyclic nucleotide phosphodiesterase
0.002
PDE3B
0.002
cAMP-specific phosphodiesterase
0.001
endothelin receptor
0.001
PDE7
0.001
PDE1A
0.001
PKG
0.001
PDE2A
0.001
phosphomonoesterase
0.001
guanylyl cyclase
0.001
PDE1C
0.001
cAMP-dependent protein kinase
0.001
calmodulin-dependent phosphodiesterase
0.001
TDP1
0.001
soluble guanylyl cyclase
0.001
adenyl cyclase
0.001
PDE10A
0.001
NPP2
0.001
dunce
0.001
NPP1
0.001
more...
Disease
PDE
0.016
erectile dysfunction
0.008
pulmonary hypertension
0.001
Pulmonary arterial hypertension
0.001
SCAN1
0.001
cholera
0.000
chronic obstructive pulmonary disease
0.000
heart failure
0.000
premature ejaculation
0.000
pertussis
0.000
asthma
0.000
sexual dysfunction
0.000
right heart failure
0.000
hypertension
0.000
NAME
0.000
acrodysostosis
0.000
congestive heart failure
0.000
persistent pulmonary hypertension of the newborn
0.000
atopic dermatitis
0.000
Primary apnoea
0.000
Hyperdynamic septic shock
0.000
intermittent claudication
0.000
Portopulmonary hypertension
0.000
EMD
0.000
retinitis pigmentosa
0.000
organic sexual dysfunction
0.000
priapism
0.000
primary pulmonary hypertension
0.000
female sexual arousal disorder
0.000
Mietens' syndrome
0.000
LCA4
0.000
Gastric mucosal lesion
0.000
Drug-induced sexual dysfunction
0.000
Peyronie's disease
0.000
psoriasis
0.000
psoriatic arthritis
0.000
Nonarteritic anterior ischemic optic neuropathy (NAION)
0.000
ischemia
0.000
GACI
0.000
sympathomimetic
0.000
more...
Symptom
Lower urinary tract symptoms
0.000
Ureteric colic
0.000
flushing
0.000
Central cyanosis
0.000
nasal congestion
0.000
Muscle fibrosis
0.000
headache
0.000
starvation
0.000
nausea
0.000
vomiting
0.000
hyperoxia
0.000
dyspnea
0.000
diarrhea
0.000
Hangover
0.000
astasia
0.000
memory loss
0.000
spasm
0.000
bitter taste
0.000
pain
0.000
ataxia
0.000
Urinary symptoms
0.000
skin pain
0.000
anesthesia
0.000
hypothermia
0.000
Periodic breathing
0.000
functional recovery
0.000
dizziness
0.000
angina
0.000
twitching
0.000
Visual symptoms
0.000
nausea and vomiting
0.000
polyuria
0.000
fatigue
0.000
despair
0.000
seizures
0.000
Decreased activity
0.000
photopsia
0.000
retching
0.000
No adverse effect
0.000
nocturnal polyuria
0.000
more...
Drug
Rolipram
0.011
Cilostazol
0.004
Vardenafil
0.003
Viagra
0.003
Roflumilast
0.003
Roflumilast
0.003
Enoximone
0.002
CIA
0.002
Viagra
0.002
Forskolin
0.001
Cilomilast
0.001
Amrinone
0.001
Levitra
0.001
Theophylline
0.001
Levitra
0.001
Pimobendan
0.001
Ibudilast
0.001
Papaverine
0.001
Avanafil
0.000
Piclamilast
0.000
Piclamilast
0.000
Levosimendan
0.000
caffeine
0.000
Vinpocetine
0.000
Quazinone
0.000
Indolidan
0.000
Piroximone
0.000
Vesnarinone
0.000
Trapidil
0.000
Propentofylline
0.000
Sodium nitroprusside
0.000
Bosentan
0.000
Bosentan
0.000
Toborinone
0.000
Anagrelide
0.000
2-Fluoroadenosine
0.000
Bemoradan
0.000
R-Rolipram
0.000
Trifluoperazine
0.000
ICI
0.000
more...
Enzyme
phosphodiesterase
1.000
PDE
0.033
exonuclease I
0.011
cGMP phosphodiesterase
0.009
adenylate cyclase
0.009
nucleotide pyrophosphatase
0.005
guanylate cyclase
0.004
protein kinase
0.002
PKG
0.001
3'-exonuclease
0.001
5'-nucleotidase
0.001
lysophospholipase D
0.001
AMPK
0.001
3'-phosphatase
0.000
glycerophosphocholine cholinephosphodiesterase
0.000
venom phosphodiesterase
0.000
glycerophosphocholine phosphodiesterase
0.000
AcpH
0.000
protein kinase C
0.000
rhodopsin kinase
0.000
alkaline phosphatase
0.000
exonuclease VII
0.000
NO synthase
0.000
adenosine deaminase
0.000
adenosine deaminase
0.000
acid phosphatase
0.000
polynucleotide kinase
0.000
yeast ribonuclease
0.000
nucleotidase
0.000
phospholipase C
0.000
myosin light chain kinase
0.000
DNA polymerase
0.000
calcineurin
0.000
ATPase
0.000
EC 3.6.1.17
0.000
mannosylphosphodolichol phosphodiesterase
0.000
EC 3.6.1.29
0.000
CMP-sialic acid hydrolase
0.000
endonuclease
0.000
RNA ligase
0.000
more...
Compound
cAMP
0.021
cGMP
0.021
Sildenafil
0.011
AMP
0.010
GMP
0.005
Milrinone
0.003
Theophylline
0.001
Forskolin
0.001
calcium
0.001
nitric oxide
0.001
2-imidazolidinone
0.001
Pentoxifylline
0.001
prostaglandin E1
0.001
prostacyclin
0.001
adenylate
0.001
Papaverine
0.001
8-Br-cGMP
0.001
SQ 20009
0.000
4-methoxybenzyl
0.000
caffeine
0.000
GTP
0.000
ATP
0.000
Dibutyryl cyclic AMP
0.000
Dibutyryl cyclic AMP
0.000
ADP
0.000
sodium
0.000
Isoproterenol
0.000
phosphate
0.000
ADP
0.000
nonyl
0.000
ADP
0.000
DEAE
0.000
Adenosine
0.000
Aminophylline
0.000
Olprinone hydrochloride
0.000
arginine
0.000
PGE2
0.000
4-methoxybenzamide
0.000
Sulmazole
0.000
Mg2+
0.000
more...