EC:3.1.4.1 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:3.1.4.1 (phosphodiesterase)
18,767 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)

.

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
phosphodiesterase	17939
AMP	2695
adenylate cyclase	1652
Sep	1300
Mol	1073
calmodulin	1041
PDE	865
ATP	730
nucleotide pyrophosphatase	684
PDE4	646
insulin	615
adenylyl cyclase	581
cyclic nucleotide phosphodiesterase	567
guanylate cyclase	565
GTP	403
GMP	398
cyclic AMP phosphodiesterase	382
PDE5	374
nitric oxide synthase	354
ADP	340
cAMP-dependent protein kinase	336
cytokine	291
PKA	280
endothelin receptor	268
rhodopsin	267
cGMP phosphodiesterase	257
ATPase	255
alkaline phosphatase	254
Phosphodiesterase	250
tumor necrosis factor	249
glucagon	240
collagen	237
phosphatase	235
PKG	231
lipopolysaccharide	219
exonuclease I	211
guanylyl cyclase	211
membrane-bound	204
5'-nucleotidase	189
polypeptide	188

Disease
erectile dysfunction	1006
PDE	865
hypertension	596
heart failure	509
cancer	498
pulmonary hypertension	473
asthma	438
tumor	365
diabetes	358
chronic obstructive pulmonary disease	339
cholera	290
pertussis	234
depression	233
stroke	233
ischemia	232
congestive heart failure	190
NAME	150
atherosclerosis	133
atopic dermatitis	132
Pulmonary arterial hypertension	128
cardiovascular disease	127
Alzheimer's disease	127
obesity	125
SDS	124
psoriasis	113
myocardial infarction	109
heart disease	102
sexual dysfunction	95
neuroblastoma	91
right heart failure	87
myocardial ischemia	82
schizophrenia	75
type 2 diabetes	75
glioma	73
coronary artery disease	72
cold	72
multiple sclerosis	72
retinitis pigmentosa	71
prostate cancer	70
HIV	70

Symptom
headache	130
pain	121
vomiting	76
starvation	74
anesthesia	72
nausea	70
diarrhea	68
dyspnea	52
flushing	51
seizures	48
fatigue	39
ataxia	29
angina	28
hypothermia	27
functional recovery	23
hyperoxia	22
cough	22
respiratory distress	21
spasm	20
nasal congestion	20
dizziness	19
nausea and vomiting	17
analgesia	17
tremor	15
Lower urinary tract symptoms	15
memory loss	14
collapse	13
syncope	13
thinning	10
hypercapnia	10
chest pain	9
myalgia	9
erythema	9
constipation	9
polyuria	9
weakness	9
acute pain	9
abdominal pain	8
bitter taste	8
twitching	8

Enzyme
phosphodiesterase	18767
adenylate cyclase	1785
protein kinase	1759
PDE	1513
guanylate cyclase	774
cGMP phosphodiesterase	409
protein kinase C	384
alkaline phosphatase	359
AMPK	348
ATPase	302
PKG	231
mitogen-activated protein kinase	223
exonuclease I	211
NO synthase	203
5'-nucleotidase	196
nucleotide pyrophosphatase	193
phospholipase C	178
acid phosphatase	163
DNA polymerase	159
calcineurin	155
thrombin	150
endonuclease	149
trypsin	132
phospholipase A2	114
adenosine deaminase	109
adenosine deaminase	106
RNase	96
peroxidase	94
renin	94
RNase	92
superoxide dismutase	87
ERK	85
acetylcholinesterase	73
3'-exonuclease	71
topoisomerase	71
DNase	68
topoisomerase	66
myosin light chain kinase	65
NOS	64
luciferase	63