Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
 18,767 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
phosphodiesterase 17939
AMP 2695
adenylate cyclase 1652
Sep 1300
Mol 1073
calmodulin 1041
PDE 865
ATP 730
nucleotide pyrophosphatase 684
PDE4 646
insulin 615
adenylyl cyclase 581
cyclic nucleotide phosphodiesterase 567
guanylate cyclase 565
GTP 403
GMP 398
cyclic AMP phosphodiesterase 382
PDE5 374
nitric oxide synthase 354
ADP 340
more...
Disease
erectile dysfunction 1006
PDE 865
hypertension 596
heart failure 509
cancer 498
pulmonary hypertension 473
asthma 438
tumor 365
diabetes 358
chronic obstructive pulmonary disease 339
cholera 290
pertussis 234
depression 233
stroke 233
ischemia 232
congestive heart failure 190
NAME 150
atherosclerosis 133
atopic dermatitis 132
Pulmonary arterial hypertension 128
more...
Symptom
headache 130
pain 121
vomiting 76
starvation 74
anesthesia 72
nausea 70
diarrhea 68
dyspnea 52
flushing 51
seizures 48
fatigue 39
ataxia 29
angina 28
hypothermia 27
functional recovery 23
hyperoxia 22
cough 22
respiratory distress 21
nasal congestion 20
spasm 20
more...
Drug
caffeine 375
Rolipram 301
Cardiovasc 296
Forskolin 240
Theophylline 182
Cilostazol 168
Viagra 166
CIA 156
Dermatol 152
Viagra 118
Vardenafil 94
Roflumilast 78
Roflumilast 78
ICI 68
Papaverine 68
Enoximone 68
Amrinone 63
nitroglycerin 62
Histamine 55
lysine 54
more...
Enzyme
phosphodiesterase 18767
adenylate cyclase 1785
protein kinase 1759
PDE 1513
guanylate cyclase 774
cGMP phosphodiesterase 409
protein kinase C 384
alkaline phosphatase 359
AMPK 348
ATPase 302
PKG 231
mitogen-activated protein kinase 223
exonuclease I 211
NO synthase 203
5'-nucleotidase 196
nucleotide pyrophosphatase 193
phospholipase C 178
acid phosphatase 163
DNA polymerase 159
calcineurin 155
more...
Compound
cAMP 4820
AMP 2862
cGMP 2848
calcium 2537
Dec 1312
nitric oxide 1177
DNA 1051
GMP 970
sodium 949
phosphate 752
ATP 731
Clin 672
oxygen 576
glucose 490
arginine 462
Sildenafil 457
GTP 403
prostacyclin 403
ADP 397
water 390
more...