Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
 18,767 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
phosphodiesterase 17939
AMP 2695
adenylate cyclase 1652
Sep 1300
Mol 1073
calmodulin 1041
PDE 865
ATP 730
nucleotide pyrophosphatase 684
PDE4 646
insulin 615
adenylyl cyclase 581
cyclic nucleotide phosphodiesterase 567
guanylate cyclase 565
GTP 403
GMP 398
cyclic AMP phosphodiesterase 382
PDE5 374
nitric oxide synthase 354
ADP 340
cAMP-dependent protein kinase 336
cytokine 291
PKA 280
endothelin receptor 268
rhodopsin 267
cGMP phosphodiesterase 257
ATPase 255
alkaline phosphatase 254
Phosphodiesterase 250
tumor necrosis factor 249
glucagon 240
collagen 237
phosphatase 235
PKG 231
lipopolysaccharide 219
guanylyl cyclase 211
exonuclease I 211
membrane-bound 204
5'-nucleotidase 189
polypeptide 188
PDE2 182
soluble guanylyl cyclase 178
Dictyostelium 170
adenosine receptor 160
Gen 159
TNF 154
thrombin 149
endonuclease 149
vasopressin 145
calcium channel 144
cyclooxygenase 142
PDE4B 132
SDS 124
pyrophosphatase 124
adenyl cyclase 122
Pseudomonas 112
olfactory 110
GDP 109
NMR 109
TNF-alpha 108
adenosine deaminase 106
PDE4A 104
natriuretic peptide 98
dimeric 97
DNA polymerase 97
CGI 94
microsomal 94
renin 94
myelin basic protein 93
Autotaxin 91
angiotensin II 90
atrial natriuretic peptide 90
beta-endorphin 90
endoplasmic reticulum 89
IL-6 88
inducible nitric oxide synthase 88
axonal 88
tyrosine kinase 86
spermatozoa 86
FSH 86
calcineurin 85
CA1 85
vasoactive intestinal peptide 83
cGMP-PDE 82
LPS 82
IgE 82
phosphomonoesterase 81
interferon 81
glycoprotein 80
GTPase 80
CREB 79
endothelin-1 78
beta 1 78
5-hydroxytryptamine 78
IL-4 78
acid phosphatase 77
superoxide dismutase 75
parathyroid hormone 73
caspase-3 73
somatostatin 73
muscarinic receptor 70
cAMP-specific phosphodiesterase 70
bradykinin 69
IL-10 68
acetylcholinesterase 67
NAD 67
PDE3B 67
calcitonin 66
epididymal 64
endothelial nitric oxide synthase 64
Rho 64
protein phosphatase 64
glial fibrillary acidic protein 62
hemoglobin 62
cardiac muscle 61
eNOS 61
myosin 60
phospholipase A2 60
ACTH 60
MAPK 59
histone 59
secretin 58
PKC 57
prolactin 57
GTP-binding protein 57
arrestin 57
ERK 56
neuronal nitric oxide synthase 56
COPD 55
Cyclic nucleotide phosphodiesterase 55
IL-5 55
myeloperoxidase 53
tyrosine hydroxylase 53
GABA 52
threonine 52
topoisomerase I 52
brain-derived neurotrophic factor 52
membrane protein 51
substance P 51
GAF 51
vascular endothelial growth factor 50
atrial natriuretic factor 50
p38 50
Aplysia 50
serum albumin 49
PDE10A 49
interferon-gamma 48
PDE7 48
vasoactive intestinal peptide (VIP) 48
NPP1 47
lactate dehydrogenase 47
albumin 47
collagenase 47
myosin light chain kinase 47
dunce 47
IL-8 47
phospholipase D 46
fused 46
tRNA 46
esterase 46
more...
Disease
erectile dysfunction 1006
PDE 865
hypertension 596
heart failure 509
cancer 498
pulmonary hypertension 473
asthma 438
tumor 365
diabetes 358
chronic obstructive pulmonary disease 339
cholera 290
pertussis 234
depression 233
stroke 233
ischemia 232
congestive heart failure 190
NAME 150
atherosclerosis 133
atopic dermatitis 132
Pulmonary arterial hypertension 128
Alzheimer's disease 127
cardiovascular disease 127
obesity 125
SDS 124
psoriasis 113
myocardial infarction 109
heart disease 102
sexual dysfunction 95
neuroblastoma 91
right heart failure 87
myocardial ischemia 82
schizophrenia 75
type 2 diabetes 75
glioma 73
multiple sclerosis 72
coronary artery disease 72
cold 72
retinitis pigmentosa 71
prostate cancer 70
melanoma 70
HIV 70
cognitive impairment 69
vascular disease 66
hepatocellular carcinoma 65
sepsis 63
sepsis 60
PSS 59
carcinoma 58
COPD 55
intermittent claudication 54
plaque 53
Parkinson's disease 53
breast cancer 52
psoriatic arthritis 51
pulmonary edema 49
Mycobacterium 48
lymphoma 48
uterus 48
hypogonadism 48
cerebral ischemia 47
cystic fibrosis 46
cardiomyopathy 46
premature ejaculation 45
leukemia 44
tuberculosis 44
lung disease 44
pruritus 43
neuropathy 43
tumor growth 43
dyspepsia 41
metabolic syndrome 40
cirrhosis 40
SEM 40
EMD 39
arthritis 39
encephalomyelitis 39
dementia 38
sympathomimetic 38
ventricular hypertrophy 37
primary pulmonary hypertension 37
impotence 36
rheumatoid arthritis 35
lung cancer 35
tumorigenesis 35
dilated cardiomyopathy 35
priapism 33
GSH 32
skin disease 32
carcinogenesis 32
hyperglycemia 32
blindness 31
Raynaud's phenomenon 31
liver disease 29
renal disease 29
memory impairment 28
connective tissue disease 28
coronary heart disease 28
major depressive disorder 28
persistent pulmonary hypertension of the newborn 28
pheochromocytoma 28
acute myocardial infarction 28
renal failure 28
PAF 27
peripheral vascular disease 26
dermatitis 25
portal hypertension 25
Brown 25
chronic bronchitis 25
Huntington's disease 25
colon cancer 24
respiratory disease 24
osteoporosis 24
scleroderma 23
tumor progression 23
immunodeficiency 23
adenocarcinoma 23
infectious diseases 23
Evans 23
eosinophilia 23
subarachnoid hemorrhage 23
hypercholesterolemia 23
astrocytoma 22
AIDS 22
colorectal cancer 22
virus infection 22
Peyronie's disease 22
pneumonia 22
MCF 22
bronchospasm 22
bronchopulmonary dysplasia 22
mole 21
epididymis 21
tetanus 21
inflammatory bowel disease 21
mole 21
autoimmune disease 21
SCH 21
metastases 21
hyperlipidemia 21
ATM 20
mental illness 20
preeclampsia 20
insulinoma 20
emphysema 19
incontinence 19
cerebral infarction 19
infertility 19
epilepsy 19
sickle cell disease 19
SCAN1 19
respiratory failure 19
Blocking 19
worms 19
thrombocytopenia 18
bipolar disorder 18
idiopathic pulmonary fibrosis 18
fits 18
Endothelial dysfunction 18
LCA 18
chronic disease 18
more...
Symptom
headache 130
pain 121
vomiting 76
starvation 74
anesthesia 72
nausea 70
diarrhea 68
dyspnea 52
flushing 51
seizures 48
fatigue 39
ataxia 29
angina 28
hypothermia 27
functional recovery 23
cough 22
hyperoxia 22
respiratory distress 21
spasm 20
nasal congestion 20
dizziness 19
analgesia 17
nausea and vomiting 17
Lower urinary tract symptoms 15
tremor 15
memory loss 14
syncope 13
collapse 13
thinning 10
hypercapnia 10
acute pain 9
chest pain 9
constipation 9
polyuria 9
weakness 9
myalgia 9
erythema 9
abdominal pain 8
agitation 8
cyanosis 8
bitter taste 8
twitching 8
overweight 8
exertional dyspnea 7
exhaustion 7
discomfort 7
insomnia 7
back pain 7
discomfort 7
despair 6
cachexia 6
colic 6
polydipsia 5
anorexia 5
pelvic pain 4
chronic cough 4
vertigo 4
incoordination 4
abdominal discomfort 3
tachypnea 3
photophobia 3
Decreased activity 3
pallor 3
ophthalmoplegia 3
arthralgia 3
dysuria 3
HSA 3
retching 3
splenomegaly 2
chorea 2
No adverse effect 2
clonus 2
shortness of breath 2
motor symptom 2
tinnitus 2
productive cough 2
acute stress 2
acidity 2
bradykinesia 2
rundown 2
blurred vision 2
astasia 2
hemoptysis 2
catatonia 2
spasticity 2
Neuropathic pain 2
autodigestion 1
urinary frequency 1
lethargy 1
POA 1
hangover 1
swollen joints 1
Spastic 1
Urinary symptoms 1
inanition 1
cerebellar ataxia 1
Welt 1
photopsia 1
numbness 1
loss of taste 1
physical appearance 1
neurological disability 1
oliguria 1
Ureteric colic 1
Excitability 1
muscle rigidity 1
rhinorrhea 1
Anoxia 1
sleepiness 1
dysarthria 1
dystonia 1
nocturnal polyuria 1
presyncope 1
Ill 1
Visual symptoms 1
enuresis 1
Involuntary Movement 1
prostatism 1
skin pain 1
Hangover 1
dry eye 1
tonic seizure 1
Wind 1
Muscle fibrosis 1
hyperacusis 1
pachyonychia 1
Noise-induced hearing loss 1
Central cyanosis 1
skin irritation 1
renal colic 1
hepatosplenomegaly 1
hypotonia 1
elbow pain 1
asynergy 1
Periodic breathing 1
wheezing 1
leg edema 1
Drug
caffeine 375
Rolipram 301
Cardiovasc 296
Forskolin 240
Theophylline 182
Cilostazol 168
Viagra 166
CIA 156
Dermatol 152
Viagra 118
Vardenafil 94
Roflumilast 78
Roflumilast 78
Enoximone 68
Papaverine 68
ICI 68
Amrinone 63
nitroglycerin 62
Histamine 55
lysine 54
Nephron 53
CaCl2 49
CaCl2 49
CaCl2 49
Gel 48
Indomethacin 46
Levosimendan 46
Glucagon 43
MAP 41
IFN-gamma 41
PTH 38
NADH 37
IL-2 35
Sodium nitroprusside 35
Levitra 31
Asthma 31
Levitra 31
ROS 29
Pimobendan 29
Cilomilast 28
Vinpocetine 27
Ibudilast 26
Salbutamol 23
Bosentan 22
Bosentan 22
Nitric Oxide 21
CSF 20
Atropine 20
Trifluoperazine 19
CTX 19
FAD 18
Asn 18
DNase I 17
Methylene blue 17
Iloprost 17
Ouabain 17
Ethanol 16
Secretin 16
Fraction 16
Vesnarinone 15
Adenosine deaminase 15
-deoxyadenosine 15
Phentolamine 14
ascorbate 14
Ringer's solution 14
CDP 14
Bayer 13
Angiotensin II 13
Trapidil 13
Apomorphine 12
Avanafil 12
EE2 12
Clonidine 11
lactose 11
ABC 10
Propentofylline 10
Heme 10
Piclamilast 9
Piclamilast 9
Anagrelide 9
ETS 9
vitamin E 9
Digitalis 8
balanced salt solution 7
Piroximone 7
Enprofylline 7
CoCl2 7
CoCl2 7
Nesiritide 7
Retinoic acid 7
Treprostinil 7
Trental 7
ETA 7
p75 7
Luteinizing 7
MgSO4 7
GRF 6
Alanine 6
Amiloride 6
Pronase 6
Xanthium 6
CTX 6
Dihydro 6
CTX 6
niacin 5
Glycerol 5
Adenosine triphosphate 5
Beraprost 5
Indolidan 5
Amiloride 5
PCP 5
Albumin 5
MRC 5
EPI 5
Fragment 5
VCR 5
Glycyrrhiza 5
NH3 5
Prednisolone 5
Portal 5
Leaf 5
Donepezil 4
Nephron 4
Meconium 4
AC2 4
Cibacron Blue 4
citric acid 4
Imatinib 4
BLM 4
Biopolymers 4
ADM 4
Cicletanine 4
Dial 4
BH4 4
CPZ 4
Docetaxel 4
Fluphenazine 4
Quazinone 4
Ranitidine 4
ROC 3
Growth hormone 3
Scopolamine 3
ampicillin 3
HCG 3
Taxol 3
Vitamin E 3
G-CSF 3
Azithromycin 3
TAT 3
L-tyrosine 3
Nimesulide 3
Fructose 3
Fluorescein 3
Ephedrae Herba 3
Cimetidine 3
Toborinone 3
Carbenoxolone 3
HPMPC 3
APD 3
Doxofylline 3
more...
Enzyme
phosphodiesterase 18767
adenylate cyclase 1785
protein kinase 1759
PDE 1513
guanylate cyclase 774
cGMP phosphodiesterase 409
protein kinase C 384
alkaline phosphatase 359
AMPK 348
ATPase 302
PKG 231
mitogen-activated protein kinase 223
exonuclease I 211
NO synthase 203
5'-nucleotidase 196
nucleotide pyrophosphatase 193
phospholipase C 178
acid phosphatase 163
DNA polymerase 159
calcineurin 155
thrombin 150
endonuclease 149
trypsin 132
phospholipase A2 114
adenosine deaminase 109
adenosine deaminase 106
RNase 96
peroxidase 94
renin 94
RNase 92
superoxide dismutase 87
ERK 85
acetylcholinesterase 73
3'-exonuclease 71
topoisomerase 71
DNase 68
topoisomerase 66
myosin light chain kinase 65
NOS 64
luciferase 63
phosphorylase 61
caspase-3 58
lactate dehydrogenase 55
collagenase 54
ACE 53
DNA ligase 50
DNA ligase 50
tyrosine hydroxylase 50
focal adhesion kinase 48
catalase 48
lysophospholipase D 47
beta-galactosidase 46
ribonuclease 46
ribonuclease 46
reverse transcriptase 46
phospholipase D 46
CPT 45
CPT 44
CPT 44
venom phosphodiesterase 43
nucleotidase 42
lipase 40
MEK 38
PARP 38
CaMKII 37
NADPH oxidase 37
hyaluronidase 36
NADPH oxidase 35
polynucleotide kinase 35
rhodopsin kinase 33
phosphatidylinositol 3-kinase 33
elastase 33
hyaluronidase 33
ACS 32
ornithine decarboxylase 32
hormone-sensitive lipase 31
beta-glucuronidase 31
3'-phosphatase 30
lipoxygenase 30
CD10 29
monoamine oxidase 29
arginase 29
RNA polymerase 28
GSK 27
AMP-activated protein kinase 27
RNA ligase 26
apyrase 26
proteasome 26
chymotrypsin 25
MAP 24
sulfatase 24
CYP3A4 24
phosphoinositide 3-kinase 23
Mg2+-ATPase 23
PAH 23
aequorin 23
CNPase 22
adenylate kinase 22
deaminase 22
deoxyribonuclease 22
xanthine oxidase 22
glutathione S-transferase 21
glutamine synthetase 20
histidine kinase 20
neuropathy target esterase 20
deoxyribonuclease 20
gamma-glutamyl transpeptidase 19
N-acetyltransferase 19
carbonic anhydrase 18
diacylglycerol kinase 18
alanine aminotransferase 18
phosphoenolpyruvate carboxykinase 18
tissue plasminogen activator 18
cholinesterase 17
thymidine kinase 17
P-glycoprotein 17
micrococcal nuclease 17
phosphoenolpyruvate carboxykinase 17
beta-lactamase 17
pyruvate kinase 17
phosphoenolpyruvate carboxykinase 17
alcohol dehydrogenase 16
arylalkylamine N-acetyltransferase 16
creatine kinase 16
alpha-mannosidase 16
NADPH-diaphorase 16
protein phosphatase 2A 16
lipoprotein lipase 16
tyrosinase 16
ADPase 16
p-nitrophenylphosphatase 15
leucine aminopeptidase 15
glucose-6-phosphatase 15
diaphorase 15
alpha-glucosidase 14
prostaglandin synthetase 14
NAD glycohydrolase 14
glutathione peroxidase 14
triphosphatase 14
glucose-6-phosphate dehydrogenase 14
DNase II 14
phosphorylase kinase 14
cdc2 13
exonuclease VII 13
ADP-ribosyltransferase 13
ADP-ribosyltransferase 13
transcriptase 13
CPR 13
aldehyde dehydrogenase 13
paraoxonase 13
succinate dehydrogenase 12
thromboplastin 12
adenosine kinase 12
neutrophil elastase 12
aspartate aminotransferase 12
hexosaminidase 11
chloramphenicol acetyltransferase 11
PI-PLC 11
RNase H 11
AMPK 10
more...
Compound
cAMP 4820
AMP 2862
cGMP 2848
calcium 2537
Dec 1312
nitric oxide 1177
DNA 1051
GMP 970
sodium 949
phosphate 752
ATP 731
Clin 672
oxygen 576
glucose 490
arginine 462
Sildenafil 457
GTP 403
prostacyclin 403
ADP 397
water 390
caffeine 375
ADP 348
ADP 340
acetate 307
prostaglandin E1 294
Cardiol 278
potassium 273
Theophylline 272
adenylate 264
Forskolin 240
noradrenaline 230
Mg2+ 225
DEAE 212
sulfate 199
tyrosine 187
PGE2 167
glutamate 154
TNF 154
glycerol 153
Isoproterenol 147
hydrogen 143
salt 140
SDS 139
manganese 138
Adenosine 138
Phe 136
serine 128
zinc 128
EDTA 127
EDTA 126
Milrinone 123
leucine 118
His 114
GDP 113
5-HT 112
alanine 108
Insulin 107
ethanol 105
Pentoxifylline 103
nitrate 101
Triton X-100 98
ammonium 98
NAD 97
bromide 96
nitrogen 95
cysteine 92
galactose 91
lysine 85
methionine 85
threonine 84
PGE 82
urea 80
8-Br-cGMP 79
pyrimidine 71
pyrimidine 71
pyridine 70
phosphorus 69
ICI 68
iron 68
Papaverine 68
NAD 67
ACh 66
PEG 62
Adrenal 60
ACTH 59
nonyl 59
nicotinamide 59
CO2 59
ADP-ribose 58
cobalt 56
Histamine 55
copper 55
H2O2 54
aldosterone 52
Dopamine 52
tryptophan 52
PMA 52
GABA 52
GABA 52
4-methoxybenzyl 51
PMA 49
CaCl2 49
HCl 49
uridine 49
TSH 49
tryptophan 48
2-imidazolidinone 48
PEG 48
tryptophan 47
Norepinephrine 47
tryptophan 47
cadmium 46
Indomethacin 45
Asp 45
CPT 44
CPT 44
iodine 43
Glucagon 43
NMDA 43
COS 43
creatinine 42
NH2 41
Carbachol 41
cyclopentyl 41
Dibutyryl cyclic AMP 40
Dibutyryl cyclic AMP 40
methanol 39
Propranolol 38
Propranolol 38
PAS 38
acetic acid 37
retinoic acid 37
Retinal 37
NADH 37
Dipyridamole 36
Dipyridamole 36
Aminophylline 36
Dipyridamole 36
Dipyridamole 36
isoquinoline 35
Phosphatidylinositol 34
glutamine 34
ACS 33
DMSO 33
GSH 33
GSH 33
TMP 33
acetonitrile 33
Guo 33
NPP 32
carbonate 32
ACS 32
proline 30
UTP 30
dipropyl 30
NADPH 30
H2S 30
1H-imidazole 30
Gly 29
NADPH 29
more...