Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.1 (
phosphodiesterase
)
18,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Monoclonal antibodies were prepared to the gamma-subunit of the cGMP phosphodiesterase. One of them gamma p-1, suppresses the activation of
phosphodiesterase
through the alpha-subunit of transducin. The gamma-subunit fragment 24-45 rich in Arg and Lys residues is involved in gamma p-1 binding and is essential for the gamma-subunit interaction with transducin.
Carboxypeptidase Y
cleaves off seven amino acid residues from the C-terminus of the gamma-subunit resulting in
phosphodiesterase
activation. Thus, the C-terminal fragment of gamma-subunit participates in
phosphodiesterase
inhibition.
...
PMID:Active sites of the cyclic GMP phosphodiesterase gamma-subunit of retinal rod outer segments. 245 57
