Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.4.1 (
phosphodiesterase
)
18,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Extracellular application of some peptides (oxytocin,
Lys-vasopressin
, Leu-enkephalin) to neuron RPal induced pacemaker potentials generation and initiated or increased bursting activity. Norepinephrine and prostaglandins E1 and E2 effects on neuron RPal electric activity were qualitatively similar to those produced by oxytocin and
Lys-vasopressin
. Dibutyryl-cAMP, papaverine (
phosphodiesterase
inhibitor) and sodium fluoride (nonspecific adenylate cyclase activator) induced or potentiated bursting activity. It is supposed that oxytocin,
Lys-vasopressin
, Leu-enkephalin, norepinephrine and E group prostaglandins effects are mediated by intracellular processes related to activation of adenylate cyclase and increase of cAMP level in the neuron.
...
PMID:[Reactions of an identified edible snail neuron to application of peptides, mediators, prostaglandins, and cyclic nucleotides]. 611 55
