Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
 18,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Highly sensitive technique are described for the assay of plasma membrane (5'-nucleotidase, alkaline phosphatase), microsomal (neutral alpha-glucosidase, leucyl-2-naphthylamidase) and biliary canalicular (gamma-glutamyltransferase) enzymes and for nine acid hydrolases (acid phosphatase, phosphodiesterase, beta-glucosidase, alpha-glucosidase, alpha-galactosidase, beta-galactosidase, alpha-mannosidase, N-acetyl-beta-glucosaminidase, beta-glucuronidase) in human liver. 2. Optimum and specific assay systems have been developed which give linear kinetics for all enzymes. 3. The range of enzyme activities in samples of human liver, obtained by closed needle biopsy, and sera have been determined.
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PMID:Enzyme activities in human liver biopsies: assay methods and activities of some lysosomal and membrane-bound enzymes in control tissue and serum. 1 4

In the newborn lamb, activities of lysosomal enzymes are lower in the duodenum and jejunum than in the ileum. In contrast, there are only minor differences, if any, in activities of lysosomal enzymes between the regions of the small intestine of 5-day-old lambs. In the duodenum, jejunum and ileum, activities of hexosaminidase, alpha-mannosidase, beta-mannosidase, alpha-L-fucosidase and phosphodiesterase are greater in newborn than in 5-day-old lambs. Only in the distal part of the small intestine are activities of beta-glucuronidase, alpha-glucosidase, alpha-galactosidase, beta-galactosidase, acid phosphatase and cathepsin B higher in the newborn than in 5-day-old lambs. Cathepsin B activity is lower in the duodenum and jejunum of the newborn than in 5-day-old lambs.
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PMID:Lysosomal enzymes in the intestine of the newborn lamb. 609 93

Activities of lysosomal hydrolases were measured in the leucocytes of cattle, sheep, goats, horses and pigs. There was high activity of arylsulphatase in leucocytes from cattle, high activities of alpha-fucosidase and beta-glucuronidase in leucocytes from horses and high activity of acid phosphatase in granulocytes from pigs. Within species, arylsulphatase and beta-galactosidase activities were higher in granulocytes than in mononuclear cells, but beta-glucuronidase, phosphodiesterase and alpha-galactosidase activities were higher in mononuclear cells than in granulocytes. Eosinophils of cattle, sheep, goats and horses contained at least 10 times the activity of alpha-mannosidase and arylsulphatase found in neutrophils. For most of the other enzymes studied, there were differences in cattle and goats but not in sheep, horses or pigs between their specific activities in neutrophils and eosinophils.
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PMID:Lysosomal hydrolase activity in leucocytes from cattle, sheep, goats, horses and pigs. 715 6