Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.4.1 (phosphodiesterase)
 18,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of acemetacin (Rantudil) and indomethacin, respectively, on coronary flow and O2-pressure in coronary sinus blood before and after i.v. injections of coronary active compounds was permanently registered in anesthetised closed-chest dogs. It was found that i.v. infections of 2 mg acemetacin/kg extended effects of i.v. injected morocromen. After administration of morocromen (4.0 mg/kg), carbocromen (2.0 mg/kg), or dipyridamole (0.4 mg/kg) the application of acemetacin or indomethacin, respectively, produced a markedly increased effect on the coronary blood vessels. Comparative studies of indole-derivatives, the Ca-antagonizing compounds prenylamine, verapamil, nifedipine, and the phosphodiesterase inhibitor papaverine showed no similar effects.
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PMID:[Interaction of coronary-active compounds and anti-inflammatory drugs on the coronary vascular system (author's transl)]. 719 46