Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.31.1 (
micrococcal nuclease
)
2,818
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The sensitivity of the mouse alpha-globin gene to
micrococcal nuclease
and its nucleosomal repeat were studied in three different functional states of the gene: inactive in EAT cells, potentially active in uninduced
MEL
cells and active in induced
MEL
cells. The results show that: 1. The nuclease sensitivity of the gene differs in the three different functional states. 2. Both the coding and the 5'-flanking regions of the induced actively transcribed gene show a typical nucleosomal repeat pattern. 3. Hypersensitive sites for
micrococcal nuclease
and for an endogenous nuclease appear upstream of the gene after induction of differentiation.
...
PMID:Presence of nucleosomal repeat in the transcribed alpha globin gene of induced murine erythroleukemia cells. 386 Nov 79
