Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.31.1 (micrococcal nuclease)
 2,818 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When fragments of H1 histone formed by bisection of H1 histone with thrombin were allowed to reassociate with H1 histone-depleted chromatin, the carboxyl-terminal segment reassociated in such a manner as to protect the micrococcal nuclease-sensitive site(s) of the nucleosome core. On the other hand, the NH2-terminal segment of H1 histone protected 20 base pairs of linker DNA adjacent to the nucleosome core particle. These data provide strong evidence that the NH2-terminal portion and the carboxyl-terminal portion of H1 histone interact with 20 base pairs of linker DNA and the core DNA of the nucleosome, respectively.
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PMID:The reassociation with chromatin of H1 fragments bisected with thrombin. 726 48