Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.31.1 (
micrococcal nuclease
)
2,818
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The structure of chromatin containing amplified
N-myc
in neuroblastoma and retinoblastoma cells was investigated using
micrococcal nuclease
digestion of isolated nuclei. The size distribution of DNA fragments containing
N-myc
, produced by
micrococcal nuclease
digestion of nuclei, was determined and compared to that of DNA containing the structural gene for dihydrofolate reductase. A perturbation of the native structure of chromatin containing
N-myc
was evident from the association of
N-myc
with more extensively digested DNA when compared with chromatin containing dihydrofolate reductase.
...
PMID:Structural features of the amplified N-myc oncogene detected by micrococcal nuclease digestion of neuroblastoma cell nuclei. 208 Sep 18
