Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
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Human Gene/Protein
C9orf84 10.7
PMS1 protein 10.7
HsSen15 10.7
BCL-3-binding protein 10.7
Lewis FT 10.7
tsal1 10.7
angel homolog 2 10.7
endonuclease 10.7
Ankyrin repeat and LEM domain-containing protein 1 10.7
DNA2-like helicase 10.7
EME2 10.3
CPSF-73 10.2
EXOG 9.7
PKX1 9.7
zinc finger, RAN-binding domain containing 3 9.7
Mariner transposase 9.7
three prime repair exonuclease 2 9.7
Micrococcus luteus UV endonuclease 9.7
peroxidasin homolog-like 9.7
protein phosphatase 1, catalytic subunit, beta isoform 9.7
YKI 9.7
DCP2 decapping enzyme 9.7
MUTY 9.7
DNA repair endonuclease XPF 9.7
H-IDH alpha 9.7
DUS3 9.7
ERCC4 protein 9.7
ape2 9.5
DNase gamma 9.4
KIAA1018 9.4
MUS81 9.3
TSEN2 9.3
EME1 9.2
MLH3 protein 9.2
zinc ion binding protein 9.2
SEN34 9.2
growth arrest and DNA-damage-inducible beta 9.2
PNLDC1 9.2
tRNA-splicing endonuclease 9.2
craniofacial development protein 1 9.2
lipocalin-interacting membrane receptor 9.2
uracil-DNA glycosylase 2 9.2
HMGXB3 9.2
PGs2 9.2
CPSF100 9.2
histone H2A.2 9.2
TATDN1 9.2
RC-74 9.2
RPC4 9.2
Mahlavu hepatocellular carcinoma 9.2
XPF 9.1
DNase X 9.1
CPSF3 9.0
APE2 9.0
AP lyase 9.0
Ribosomal protein S3 8.9
FEN1 8.9
Spo11 homolog 8.8
RAS protein activator-like 1 8.7
ISY1 8.7
BL44 8.7
Mitochondrial DNA polymerase gamma 8.7
RPP38 8.7
Transmembrane channel-like protein 1 8.7
RPC3 8.7
HARBI1 8.7
transcription factor 17 8.7
BTBD12 8.7
REF1 8.7
tRNase Z 8.7
rpS3 8.7
flap endonuclease 1 8.6
TRAF and TNF receptor-associated protein 8.6
MUS81 endonuclease 8.6
polynucleotide ligase 8.6
PNO1 8.5
SMG-5 8.4
SMG-7 8.4
type I collagen alpha 1 chain 8.4
CNOT10 8.4
more...
Disease
Swine Disease 9.2
XPG/CS 9.2
Septicemic pasteurellosis 9.2
XPF 9.1
HAE III 8.7
Moraxella catarrhalis infection 8.7
Deficiency Disease 8.4
Bovine herpes mammillitis 8.2
XPG 8.0
USH2B 7.6
ATCAY 7.4
Schizophrenia and other psychotic disorders 7.3
CMO II deficiency 7.3
Tanapox 7.2
Egg drop syndrome 7.0
Airsacculitis 7.0
CYP2A6*3 7.0
mammillitis 7.0
X-linked alpha-thalassemia/mental retardation syndrome 6.9
RS-SCID 6.9
AKV 6.9
NPHP2 6.8
sphingomyelinosis 6.7
Vitiligo vulgaris 6.7
EBS1 6.7
Enterobacter bacteremia 6.7
activation of latent virus 6.7
MILS 6.7
Fowl cholera 6.5
HML 6.5
Hb SC disease 6.5
BBS12 6.3
Hemorrhagic septicemia 6.3
XP-A 6.3
Enterobacter infections 6.3
Leptospira infections 6.3
xeroderma pigmentosum 6.3
Diffuse cutaneous leishmaniasis 6.2
Pleuropneumonia 6.2
Xeroderma 6.2
Carbohydrate-deficient glycoprotein syndrome 6.2
EBS2 6.2
Adynamic bone disease 6.2
Glasser's disease 6.1
PCAP 6.1
Shope fibroma 6.1
myeloblastosis 6.1
HPFH 6.1
acute conjunctivitis 6.0
Duck plague 6.0
XPB 6.0
IS2 5.9
Legionella pneumophila pneumonia 5.8
hereditary persistence of fetal hemoglobin 5.8
laryngotracheitis 5.7
Cockayne syndrome 5.7
RP4 5.7
pseudocowpox 5.6
MKS3 5.6
Isolated growth hormone deficiency 5.6
CDA I 5.6
enterovirus meningitis 5.6
Serratia marcescens infection 5.5
EPPS 5.5
neurofibromatosis-Noonan syndrome 5.5
ALS4 5.5
IS1 5.5
HMR 5.5
Fowlpox 5.5
BRCAX 5.4
Steroid 21-hydroxylase deficiency 5.3
Sclerosing hemangioma 5.3
hereditary anemia 5.3
Neonatal herpes simplex 5.3
pyruvate kinase deficiency 5.3
PPR1 5.3
ovarian tumors of low malignant potential 5.3
alpha thalassemia 5.2
FANCI 5.2
gingivostomatitis 5.2
more...
Symptom
autodigestion 5.9
penile lesion 4.6
Inflammatory pain 4.5
DNA marker 4.3
astasia 3.8
Spots 2.9
ACHE 2.9
Involuntary Movement 2.1
skin damage 1.8
adenitis 1.6
pleuritic chest pain 1.5
collapse 1.3
pallor 1.0
diarrhea 0.8
emaciation 0.7
microbial colonization 0.7
eds 0.7
starvation 0.7
masculinization 0.4
dry eye 0.4
nasal discharge 0.3
bitter taste 0.3
hepatosplenomegaly 0.2
erythema 0.1
hypocapnia 0.0
hyperoxia -0.0
incoordination -0.1
cerebellar ataxia -0.1
memory loss -0.1
splenomegaly -0.2
ataxia -0.2
chorea -0.3
rhinorrhea -0.4
paraparesis -0.7
sore throat -0.7
acidity -0.8
polyuria -0.8
myalgia -0.9
ophthalmoplegia -1.0
dysarthria -1.1
weakness -1.1
chills -1.3
acute stress -1.4
syncope -1.4
paresthesia -1.5
lethargy -1.7
hypothermia -1.8
hepatomegaly -1.8
hypotonia -1.8
spasticity -1.9
respiratory distress -1.9
stigma -2.0
functional recovery -2.0
anorexia -2.0
arthralgia -2.1
nausea -2.2
dystonia -2.3
dyspnea -2.4
constipation -2.6
angina -2.6
Ill -2.7
agitation -2.8
exhaustion -3.0
headache -3.0
abdominal pain -3.2
vomiting -3.2
fatigue -3.3
seizures -3.6
discomfort -3.7
discomfort -3.8
overweight -3.9
pain -4.7
Drug
Camphorin 9.7
Sinefungin 6.5
Blenoxane 6.4
Ts-1 6.2
2-Methoxyethanol 6.1
NAH 6.1
DNase I 5.5
Peramivir 5.4
Gly-Tyr-Gly 5.3
BLM 5.3
AGG 5.0
MZM 5.0
Neocarzinostatin 5.0
PBZ 4.9
AKM 4.9
Protamine sulfate 4.8
Deoxyadenosine 4.8
Elm 4.7
Ranitidine hydrochloride 4.7
CTT 4.6
Zebularine 4.6
Ceredase 4.6
Relenza 4.4
PDGF B-chain 4.3
Fragment 4.3
FLP 4.3
URF 4.2
ID2 4.2
Ddc 4.1
Doxapram 4.1
ZnCl2 4.1
ZnCl2 4.1
Cerezyme 4.1
-deoxyadenosine 4.0
ISP 3.9
G418 3.8
ampicillin 3.6
KAN 3.6
Rhamnose 3.6
CLS 3.6
PMEA 3.5
ROX 3.5
Dithranol 3.5
TTC 3.5
Lactic Acid 3.4
DEL 3.3
Monarch 3.3
Mutagen 3.2
CED 3.2
Idarubicin 3.0
Rifaximin 3.0
AraC 3.0
Parlodel 3.0
Etoposide 2.9
Gel 2.9
ARA-C 2.9
Moxifloxacin 2.9
Fludarabine 2.9
Peridex 2.9
Glucantime 2.9
Desferal 2.8
Rasburicase 2.8
Clodronate 2.7
Dihydro 2.7
CTC 2.7
GNA 2.7
Desferal 2.6
Myricetin 2.5
CoCl2 2.5
CoCl2 2.5
Vena 2.4
Vena 2.4
CPZ 2.4
VCR 2.4
CTC 2.4
Pronase 2.4
CaCl2 2.4
CaCl2 2.4
AC2 2.3
Mycophenolic acid 2.3
more...
Enzyme
endonuclease 10.7
DNase V 9.9
L-idonate dehydrogenase 9.7
exoribonuclease H 9.7
DNA 3'-phosphatase 9.4
restriction-modification system 9.4
type II restriction enzyme 9.3
endodeoxyribonuclease 9.2
splicing endonuclease 9.2
AP lyase 9.2
endonuclease V 8.9
Escherichia coli exonuclease III 8.9
endonuclease VII 8.6
tRNase Z 8.6
6-aminohexanoate-cyclic-dimer hydrolase 8.2
4-oxalocrotonate decarboxylase 8.0
3'-exonuclease 8.0
RNase M5 7.9
3'-phosphatase 7.9
lambda exonuclease 7.9
DNase II 7.9
alanine-valine transaminase 7.7
adenosylmethionine hydrolase 7.7
kanamycin kinase 7.6
L-fuculose 1-phosphate aldolase 7.6
L-fuculokinase 7.6
deoxyribonuclease 7.5
CbiZ 7.4
Fpg protein 7.4
dCTPase 7.4
RNase III 7.4
exonuclease V 7.3
phosphoenolpyruvate-protein phosphotransferase 7.3
hypoxanthine-DNA glycosylase 7.3
polynucleotide kinase 7.3
DNA ligase 7.3
violaxanthin de-epoxidase 7.3
DNA ligase 7.3
exonuclease VII 7.2
viomycin phosphotransferase 7.2
L-fucose isomerase 7.0
transaminase C 7.0
6-aminohexanoate-dimer hydrolase 7.0
dCMP hydroxymethylase 7.0
exodeoxyribonuclease 7.0
exonuclease I 6.9
venom phosphodiesterase 6.7
Tpt1 6.7
RNase P 6.7
AlkA 6.7
deoxyribonuclease 6.7
DNA methyltransferase 6.7
3-methyladenine DNA glycosylase I 6.7
sucrose-phosphatase 6.6
UDP-sugar hydrolase 6.6
2-oxopent-4-enoate hydratase 6.5
formyl-CoA transferase 6.5
DNase 6.4
tryptophan 2-monooxygenase 6.3
2-hydroxymuconic semialdehyde dehydrogenase 6.3
RNase D 6.3
phosphotransbutyrylase 6.2
exoribonuclease 6.2
TUT 6.0
RNase H 6.0
RNA ligase 6.0
S1 nuclease 6.0
DNA polymerase 5.9
muconolactone isomerase 5.9
corticosterone methyl oxidase 5.8
N-acetylglucosaminyltransferase II 5.8
micrococcal nuclease 5.8
GTF-S 5.8
polynucleotide phosphorylase 5.8
MAT 5.8
MAT 5.6
2,3-dihydroxybiphenyl dioxygenase 5.5
ATase 5.4
nicotinamide adenine dinucleotide glycohydrolase 5.4
dCTP deaminase 5.4
more...
Compound
6-(p-Hydroxyphenylazo)uracil 10.7
4-Thiothymidine 9.7
4-Thiothymidine 9.7
4-Thiothymidine 9.7
2-Thioxanthine 9.7
5,6-Dihydrothymine 9.2
deoxyribose-5-phosphate 8.8
RI-64 8.4
Lucanthone 8.3
N-Lauroylsarcosine 8.2
3-hydroxy-4H-pyran-4-one 7.7
N-Acetyl-L-tyrosine 7.7
Deoxyinosine 7.6
Deoxyribonolactone 7.6
C5H10O2 7.4
Hexylamine 7.3
NAAAF 7.2
BQA 6.9
Ac-Tyr-OEt 6.9
undecanamide 6.9
4-aminobenzamide 6.9
Neomycin B 6.9
A 186 6.8
7H-dibenzo[c,g]carbazole 6.8
2,3-dimethylphenol 6.7
2,2-bis(bromomethyl)-1,3-propanediol 6.7
3-dehydroshikimic acid 6.5
RP 1 6.4
beta-Ionone 6.3
GANU 6.3
BSX 6.3
5-methylnicotinamide 6.3
BSX 6.3
Aurin 6.2
methyl methanesulfonate 6.2
Distamycin A 6.1
GANU 6.0
Solanine 6.0
XTP 6.0
M 14 6.0
beta-Ionone 6.0
4-phenyl-2-butanone 5.9
M 14 5.9
4-NQO 5.9
Solanine 5.8
3-chlorobenzoic acid 5.8
8-Hydroxyguanine 5.8
4-phenyl-2-butanone 5.8
dITP 5.8
3-ethylphenol 5.7
Deoxyribonucleic acid 5.7
Acridone 5.6
3,4-dimethylphenol 5.6
4-phenylbutanoic acid 5.6
dCMP 5.5
Agarose 5.5
Chlorhexidine diacetate 5.5
Tosylate 5.4
Uracil 5.4
HN3 5.4
X 21 5.3
Fludarabine phosphate 5.3
dIMP 5.3
XPA 5.3
dADP 5.3
XPA 5.3
3'-UMP 5.3
SAU 5.3
3-chlorobenzoic acid 5.3
A-14 5.2
DCH 5.2
Diethyl pyrocarbonate 5.2
L-methylmalonyl-CoA 5.2
5-Methylcytosine 5.2
SC-1 5.2
Chlorhexidine diacetate 5.2
SC-1 5.1
Diepoxybutane 5.1
dCTP 5.1
3-aminobenzamide 5.0
more...