Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
 18,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A classification system is presented to distinguish 3 corn nucleases-Ribonuclease I, Ribonuclease II, and Nuclease I-which were described in the first paper of this series. The 2 ribonucleases are specific for RNA, are endonucleases, and liberate purine and pyrimidine cyclic nucleotides from dinucleotide monophosphates as well as from RNA. Ribonuclease I and II hydrolyze the purine cyclic nucleotides to 3'-nucleotides, while Ribonuclease II may also act on the pyrimidine cyclic nucleotides. Ribonuclease II is best characterized by its molecular weight of 17,000, by a higher pH optimum than Ribonuclease I, and by its absorption onto microsomes.Nuclease I is a partially purified endonuclease which produces 5'-nucleotides from RNA, DNA, and dinucleotide monophosphates. The same enzyme may also be a 3'-nucleotidase.The corn nucleases were compared with nucleases found in other plant species.
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PMID:Plant Nucleases. II. Properties of Corn Ribonucleases I and II and Corn Nuclease I. 1665 17