Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
 18,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

alpha-Acetoxy-N-nitrosopyrrolidine (AcO-NPYR), in the presence of esterase, was reacted with the plasmid pBR322. The AcO-NPYR-treated plasmid was nicked by reaction with spermidine, suggesting the presence of apurinic sites. The treated plasmid also blocked the action of the restriction endonuclease BglI and, to a lesser extent, DraI. The recognition sequences of these restriction enzymes suggest that AcO-NPYR interacts preferentially with guanine and/or cytosine bases in DNA.
 ...
PMID:Interaction of alpha-acetoxy-N-nitrosopyrrolidine with DNA assessed by loss of restriction endonuclease recognition sites and formation of apurinic/apyrimidinic sites. 284 82