Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.30.2 (
endonuclease
)
18,621
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Laryngeal squamous cell carcinoma
(LSCC) is one of the most common malignant tumors in the head and neck area. Melanoma-associated antigens A (MAGE-A) are strictly tumor-specific and are expressed in several types of tumors. To date, no studies have reported the potential of
MAGE-A
genes as markers for circulating tumor cells (CTCs) in patients with LSCC. The present study aimed to evaluate the expression and the possible prognostic significance of
MAGE-A
in the peripheral blood of patients with LSCC. In the present study, the expression of
MAGE-A
genes was determined by multiplex semi-nested PCR and restriction
endonuclease
treatment of the peripheral blood of patients with LSCC. The association between
MAGE-A
gene expression and clinicopathological parameters and prognosis was evaluated. The results demonstrated that the expression of
MAGE-A
was associated with the predictors that indicate poor prognosis. The expression levels of
MAGE-A
and each individual
MAGE-A
gene were also associated with a shorter overall survival time of patients with LSCC. In conclusion, the results of the present study suggested that the expression of
MAGE-A
genes may be a potential prognostic marker for patients with LSCC.
...
PMID:MAGE-A genes as predictors of the outcome of laryngeal squamous cell carcinoma. 3279 12
